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Zinc in PDB 5chv: Crystal Structure of USP18-ISG15 Complex

Protein crystallography data

The structure of Crystal Structure of USP18-ISG15 Complex, PDB code: 5chv was solved by G.Fritz, A.Basters, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.31 / 3.01
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 64.040, 72.806, 217.259, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 28.6

Other elements in 5chv:

The structure of Crystal Structure of USP18-ISG15 Complex also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of USP18-ISG15 Complex (pdb code 5chv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of USP18-ISG15 Complex, PDB code: 5chv:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5chv

Go back to Zinc Binding Sites List in 5chv
Zinc binding site 1 out of 2 in the Crystal Structure of USP18-ISG15 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of USP18-ISG15 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:57.5
occ:1.00
SG A:CYS178 2.2 67.8 1.0
SG A:CYS229 2.2 92.4 1.0
SG A:CYS226 2.4 84.3 1.0
SG A:CYS175 2.5 52.8 1.0
CB A:CYS226 3.2 70.2 1.0
CB A:CYS175 3.3 48.7 1.0
N A:CYS229 3.3 80.0 1.0
CB A:CYS178 3.3 48.9 1.0
CB A:CYS229 3.4 82.5 1.0
N A:CYS178 3.8 55.6 1.0
CB A:SER228 3.9 89.0 1.0
CA A:CYS229 4.0 86.9 1.0
CA A:CYS178 4.1 48.5 1.0
C A:SER228 4.4 81.1 1.0
OG1 A:THR233 4.5 64.6 1.0
CA A:SER228 4.5 80.3 1.0
CA A:CYS226 4.6 82.2 1.0
N A:SER228 4.6 86.4 1.0
OG A:SER228 4.7 79.0 1.0
CA A:CYS175 4.8 49.6 1.0
CB A:ALA180 4.8 39.5 1.0
C A:CYS178 4.8 49.0 1.0
C A:GLY177 4.9 57.4 1.0
C A:CYS226 4.9 84.8 1.0

Zinc binding site 2 out of 2 in 5chv

Go back to Zinc Binding Sites List in 5chv
Zinc binding site 2 out of 2 in the Crystal Structure of USP18-ISG15 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of USP18-ISG15 Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn401

b:0.3
occ:1.00
SG B:CYS229 2.3 0.8 1.0
SG B:CYS178 2.3 78.6 1.0
SG B:CYS175 2.4 93.1 1.0
SG B:CYS226 2.4 0.1 1.0
CB B:CYS175 3.1 68.3 1.0
CB B:CYS226 3.2 0.8 1.0
CB B:CYS178 3.3 73.3 1.0
N B:CYS178 3.6 75.2 1.0
CB B:CYS229 3.6 0.2 1.0
N B:CYS229 3.8 0.0 1.0
CA B:CYS178 4.0 76.9 1.0
OG1 B:THR233 4.1 0.8 1.0
CB B:SER228 4.3 0.3 1.0
CA B:CYS229 4.3 0.6 1.0
CA B:CYS175 4.6 67.7 1.0
C B:GLY177 4.7 78.4 1.0
CA B:CYS226 4.7 0.1 1.0
C B:CYS178 4.8 73.1 1.0
CH2 B:TRP235 4.8 84.0 1.0
C B:SER228 4.9 0.2 1.0
CA B:GLY177 4.9 84.1 1.0
N B:THR179 5.0 62.4 1.0
CA B:SER228 5.0 0.4 1.0

Reference:

A.Basters, P.P.Geurink, A.Rocker, K.F.Witting, R.Tadayon, S.Hess, M.S.Semrau, P.Storici, H.Ovaa, K.P.Knobeloch, G.Fritz. Structural Basis of the Specificity of USP18 Toward ISG15. Nat. Struct. Mol. Biol. V. 24 270 2017.
ISSN: ESSN 1545-9985
PubMed: 28165509
DOI: 10.1038/NSMB.3371
Page generated: Sun Oct 27 14:22:17 2024

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