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Zinc in PDB 4z4p: Structure of the MLL4 Set Domain

Enzymatic activity of Structure of the MLL4 Set Domain

All present enzymatic activity of Structure of the MLL4 Set Domain:
2.1.1.43;

Protein crystallography data

The structure of Structure of the MLL4 Set Domain, PDB code: 4z4p was solved by Z.Zhang, A.Mittal, J.Reid, S.Reich, S.J.Gamblin, J.R.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.96 / 2.20
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 38.299, 40.692, 50.965, 90.00, 109.78, 90.00
R / Rfree (%) 19.3 / 24.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of the MLL4 Set Domain (pdb code 4z4p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of the MLL4 Set Domain, PDB code: 4z4p:

Zinc binding site 1 out of 1 in 4z4p

Go back to Zinc Binding Sites List in 4z4p
Zinc binding site 1 out of 1 in the Structure of the MLL4 Set Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the MLL4 Set Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn5601

b:33.4
occ:1.00
SG A:CYS5527 2.2 30.4 1.0
SG A:CYS5525 2.2 32.1 1.0
SG A:CYS5532 2.4 33.7 1.0
SG A:CYS5477 2.5 35.3 1.0
CB A:CYS5532 3.1 41.4 1.0
CB A:CYS5527 3.3 30.5 1.0
CB A:CYS5477 3.5 30.1 1.0
CB A:CYS5525 3.5 35.7 1.0
CA A:CYS5532 3.6 41.3 1.0
N A:CYS5527 4.0 30.6 1.0
N A:CYS5477 4.0 28.4 1.0
CA A:CYS5527 4.2 30.3 1.0
N A:ARG5533 4.2 41.5 1.0
C A:CYS5532 4.3 44.4 1.0
NE2 A:HIS5475 4.3 31.8 1.0
CA A:CYS5477 4.3 30.9 1.0
CD2 A:HIS5475 4.5 28.6 1.0
N A:LYS5534 4.5 41.4 1.0
C A:CYS5525 4.6 36.0 1.0
CA A:CYS5525 4.6 32.2 1.0
N A:GLY5528 4.7 38.3 1.0
C A:CYS5527 4.8 33.6 1.0
N A:HIS5526 4.9 27.8 1.0
O A:CYS5525 4.9 31.7 1.0
N A:CYS5532 4.9 44.1 1.0

Reference:

Y.Zhang, A.Mittal, J.Reid, S.Reich, S.J.Gamblin, J.R.Wilson. Evolving Catalytic Properties of the Mll Family Set Domain. Structure V. 23 1921 2015.
ISSN: ISSN 0969-2126
PubMed: 26320581
DOI: 10.1016/J.STR.2015.07.018
Page generated: Sun Oct 27 11:36:49 2024

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