Zinc in PDB 4tz9: Structure of Metallo-Beta-Lactamase

The structure of Structure of Metallo-Beta-Lactamase, PDB code: 4tz9 was solved by J.A.Ferguson, J.Brem, A.Makena, A.M.Mcdonough, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	2.19 / 2.13
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	120.908, 120.908, 90.190, 90.00, 90.00, 90.00
R / Rfree (%)	22.9 / 24.9

The structure of Structure of Metallo-Beta-Lactamase also contains other interesting chemical elements:

Nickel	(Ni)	4 atoms
Cobalt	(Co)	1 atom
Cadmium	(Cd)	1 atom

The binding sites of Zinc atom in the Structure of Metallo-Beta-Lactamase (pdb code 4tz9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Metallo-Beta-Lactamase, PDB code: 4tz9:

Zinc binding site 1 out of 1 in the Structure of Metallo-Beta-Lactamase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Metallo-Beta-Lactamase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:27.1 occ:1.00 ND1 A:HIS122 2.0 33.3 1.0 NE2 A:HIS189 2.0 29.8 1.0 NE2 A:HIS120 2.0 22.9 1.0 O A:HOH411 2.1 36.8 1.0 CE1 A:HIS120 2.9 25.5 1.0 CD2 A:HIS189 3.0 26.2 1.0 CE1 A:HIS122 3.0 34.5 1.0 CG A:HIS122 3.0 31.8 1.0 CE1 A:HIS189 3.1 30.8 1.0 CD2 A:HIS120 3.1 24.0 1.0 CB A:HIS122 3.3 30.3 1.0 CD A:CD304 3.6 32.5 1.0 OD1 A:ASP124 4.0 29.3 1.0 ND1 A:HIS120 4.0 27.4 1.0 NE2 A:HIS122 4.1 34.5 1.0 CG A:HIS189 4.1 25.4 1.0 CD2 A:HIS122 4.1 32.4 1.0 ND1 A:HIS189 4.2 28.1 1.0 SG A:CYS208 4.2 28.9 1.0 CG A:HIS120 4.2 24.9 1.0 CB A:CYS208 4.3 31.2 1.0 O A:HOH493 4.4 39.9 1.0 CG2 A:THR190 4.5 24.9 1.0 O A:HOH490 4.6 16.7 1.0 OD2 A:ASP124 4.8 34.6 1.0 CA A:HIS122 4.8 28.5 1.0 CG A:ASP124 4.8 33.5 1.0

J.A.Ferguson, A.Makena, J.Brem, A.M.Mcdonough, C.J.Schofield. Structure of Metallo-Beta-Lactamase To Be Published.