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Zinc in PDB 4qsi: Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- ChlorobenzenesulfonamideEnzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide:
4.2.1.1; Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide, PDB code: 4qsi
was solved by
E.Manakova,
A.Smirnov,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4qsi:
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide
(pdb code 4qsi). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide, PDB code: 4qsi: Zinc binding site 1 out of 1 in 4qsiGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 5-{[(4- Tert-Buthyl-6-Oxo-1,6-Dihydropyrimidin-2-Yl)Thio]Acetyl}-2- Chlorobenzenesulfonamide
![]() Mono view ![]() Stereo pair view
Reference:
M.Kisonaite,
A.Zubriene,
E.Capkauskaite,
A.Smirnov,
J.Smirnoviene,
V.Kairys,
V.Michailoviene,
E.Manakova,
S.Grazulis,
D.Matulis.
Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with A Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII Plos One V. 9 14106 2014.
Page generated: Sun Oct 27 06:44:28 2024
ISSN: ESSN 1932-6203 PubMed: 25493428 DOI: 10.1371/JOURNAL.PONE.0114106 |
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