Atomistry » Zinc » PDB 4q47-4q8w » 4q8u
Atomistry »
  Zinc »
    PDB 4q47-4q8w »
      4q8u »

Zinc in PDB 4q8u: Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate, PDB code: 4q8u was solved by M.Neeb, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.10 / 1.31
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 89.751, 64.490, 70.896, 90.00, 93.15, 90.00
R / Rfree (%) 14 / 16.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate (pdb code 4q8u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate, PDB code: 4q8u:

Zinc binding site 1 out of 1 in 4q8u

Go back to Zinc Binding Sites List in 4q8u
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) in Complex with Methyl 4-[2-({6- Amino-8-Oxo-1H,7H,8H-Imidazo[4,5-G]Quinazolin-2-Yl}Amino) Ethyl]Benzoate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:14.8
occ:1.00
 ND1 A:HIS349 2.1 13.8 1.0
SG A:CYS323 2.3 15.5 1.0
SG A:CYS320 2.3 14.9 1.0
SG A:CYS318 2.3 17.0 1.0
CE1 A:HIS349 2.9 15.1 1.0
CG A:HIS349 3.2 13.0 1.0
CB A:CYS323 3.3 15.6 1.0
CB A:CYS318 3.3 18.0 1.0
CB A:CYS320 3.4 14.9 1.0
CB A:HIS349 3.7 13.1 1.0
N A:CYS323 3.9 14.6 1.0
CA A:HIS349 4.1 12.4 1.0
NE2 A:HIS349 4.1 15.0 1.0
N A:CYS320 4.1 17.2 1.0
CA A:CYS323 4.2 15.8 1.0
CA A:CYS320 4.2 15.8 1.0
CD2 A:HIS349 4.3 13.5 1.0
O A:HIS349 4.5 12.9 1.0
CA A:CYS318 4.6 19.0 1.0
O A:CYS320 4.7 16.2 1.0
C A:CYS320 4.7 15.9 1.0
C A:CYS318 4.7 19.6 1.0
C A:HIS349 4.8 12.6 1.0
CB A:VAL322 4.8 14.8 1.0
O A:CYS318 4.9 19.8 1.0
C A:VAL322 4.9 15.0 1.0

Reference:

M.Neeb, C.Hohn, A.Heine, F.Diederich, G.Klebe. Addressing A New Subpocket of Tgt By Elongated 2-Amino-Lin-Benzoguanines To Be Published.
Page generated: Sun Oct 27 06:22:34 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy