Zinc in PDB 4ov9: Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate

All present enzymatic activity of Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate:
2.3.3.13;

The structure of Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate, PDB code: 4ov9 was solved by Z.Zhang, J.Wu, C.Wang, P.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.20
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	131.354, 131.354, 46.719, 90.00, 90.00, 120.00
R / Rfree (%)	16.1 / 19.3

The binding sites of Zinc atom in the Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate (pdb code 4ov9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate, PDB code: 4ov9:

Zinc binding site 1 out of 1 in the Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Isopropylmalate Synthase Binding with Alpha- Isopropylmalate within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:23.7 occ:1.00 OAD A:VPM402 2.1 21.7 1.0 OD2 A:ASP15 2.1 17.1 1.0 NE2 A:HIS209 2.1 14.3 1.0 OAG A:VPM402 2.2 25.3 1.0 NE2 A:HIS207 2.2 15.7 1.0 O A:HOH514 2.2 21.9 1.0 CAJ A:VPM402 3.0 24.5 1.0 CE1 A:HIS209 3.0 16.2 1.0 CAL A:VPM402 3.1 25.4 1.0 CD2 A:HIS209 3.2 14.4 1.0 CG A:ASP15 3.2 17.5 1.0 CE1 A:HIS207 3.2 15.9 1.0 CD2 A:HIS207 3.2 15.6 1.0 OD1 A:ASP15 3.6 20.4 1.0 OAE A:VPM402 3.8 36.8 1.0 OD1 A:ASN243 3.9 22.4 1.0 CAH A:VPM402 3.9 29.0 1.0 NH2 A:ARG14 4.1 17.2 1.0 OAF A:VPM402 4.1 23.2 1.0 O A:HOH531 4.2 19.2 1.0 ND1 A:HIS209 4.2 16.2 1.0 CG A:HIS209 4.3 13.6 1.0 CAK A:VPM402 4.3 22.2 1.0 CAI A:VPM402 4.3 33.0 1.0 NH1 A:ARG14 4.3 19.8 1.0 ND1 A:HIS207 4.3 15.7 1.0 CG A:HIS207 4.4 15.1 1.0 CAB A:VPM402 4.4 19.4 1.0 CB A:ASP15 4.5 17.8 1.0 CZ A:ARG14 4.7 17.9 1.0 CG A:ASN243 4.7 17.7 1.0 ND2 A:ASN243 4.7 15.1 1.0

Z.Zhang, J.Wu, W.Lin, J.Wang, H.Yan, W.Zhao, J.Ma, J.Ding, P.Zhang, G.Zhao. Subdomain II of Alpha-Isopropylmalate Synthase Is Essential For Activity: Inferring A Mechanism of Feedback Inhibition To Be Published.