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Atomistry » Zinc » PDB 4nuo-4o6s » 4nw7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4nuo-4o6s » 4nw7 » |
Zinc in PDB 4nw7: PDE4 Catalytic DomainEnzymatic activity of PDE4 Catalytic Domain
All present enzymatic activity of PDE4 Catalytic Domain:
3.1.4.17; Protein crystallography data
The structure of PDE4 Catalytic Domain, PDB code: 4nw7
was solved by
D.Fox Iii,
T.E.Edwards,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4nw7:
The structure of PDE4 Catalytic Domain also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the PDE4 Catalytic Domain
(pdb code 4nw7). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the PDE4 Catalytic Domain, PDB code: 4nw7: Zinc binding site 1 out of 1 in 4nw7Go back to![]() ![]()
Zinc binding site 1 out
of 1 in the PDE4 Catalytic Domain
![]() Mono view ![]() Stereo pair view
Reference:
T.J.Hagen,
X.Mo,
A.B.Burgin,
D.Fox,
Z.Zhang,
M.E.Gurney.
Discovery of Triazines As Selective PDE4B Versus PDE4D Inhibitors. Bioorg.Med.Chem.Lett. V. 24 4031 2014.
Page generated: Sun Oct 27 03:23:40 2024
ISSN: ISSN 0960-894X PubMed: 24998378 DOI: 10.1016/J.BMCL.2014.06.002 |
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