Zinc in PDB 4nw3: Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna

The structure of Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna, PDB code: 4nw3 was solved by C.Bian, W.Tempel, X.Chao, J.R.Walker, C.Bountra, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.82
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	70.327, 40.225, 60.959, 90.00, 93.51, 90.00
R / Rfree (%)	21.8 / 26.6

The binding sites of Zinc atom in the Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna (pdb code 4nw3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna, PDB code: 4nw3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1301 b:84.5 occ:1.00 SG A:CYS1189 2.3 78.8 1.0 SG A:CYS1173 2.3 81.1 1.0 SG A:CYS1167 2.3 93.7 1.0 SG A:CYS1170 2.4 89.3 1.0 CB A:CYS1189 3.2 78.9 1.0 CB A:CYS1173 3.3 86.1 1.0 CB A:CYS1167 3.5 93.8 1.0 N A:CYS1167 3.5 90.0 1.0 CB A:CYS1170 3.5 92.1 1.0 CA A:CYS1189 3.6 76.1 1.0 N A:LYS1190 3.7 77.8 1.0 CA A:CYS1167 3.9 92.2 1.0 C A:CYS1189 4.0 77.0 1.0 N A:GLY1168 4.0 93.8 1.0 N A:CYS1173 4.1 86.8 1.0 N A:CYS1170 4.2 91.3 1.0 CA A:CYS1173 4.2 86.3 1.0 CA A:CYS1170 4.4 90.9 1.0 C A:CYS1167 4.4 94.1 1.0 N A:MET1191 4.4 78.4 1.0 C A:ASP1166 4.6 89.0 1.0 CA A:LYS1190 4.7 80.2 1.0 CG A:MET1191 4.8 86.7 1.0 CA A:ASP1166 4.9 83.3 1.0 CB A:LYS1190 4.9 81.5 1.0 C A:CYS1170 5.0 89.8 1.0 N A:VAL1169 5.0 89.9 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mll Cxxc Domain in Complex with A Cpg Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1302 b:82.2 occ:1.00 SG A:CYS1161 2.3 80.5 1.0 SG A:CYS1155 2.3 98.4 1.0 SG A:CYS1194 2.4 93.1 1.0 SG A:CYS1158 2.4 81.1 1.0 CB A:CYS1161 3.4 83.9 1.0 N A:CYS1155 3.4 93.1 1.0 CB A:CYS1158 3.4 82.6 1.0 CB A:CYS1194 3.5 89.8 1.0 CB A:CYS1155 3.6 1.0 1.0 N A:GLY1156 3.6 87.9 1.0 N A:CYS1158 3.8 83.0 1.0 CA A:CYS1155 3.8 96.6 1.0 C A:CYS1155 4.0 92.7 1.0 CA A:CYS1194 4.1 86.8 1.0 N A:GLN1157 4.1 89.0 1.0 CA A:CYS1158 4.2 80.8 1.0 N A:GLN1195 4.2 87.3 1.0 N A:CYS1161 4.5 80.1 1.0 C A:ARG1154 4.5 93.0 1.0 CA A:GLY1156 4.5 86.7 1.0 CA A:CYS1161 4.5 83.1 1.0 N A:ASN1196 4.5 97.0 1.0 C A:CYS1194 4.6 86.3 1.0 O A:CYS1158 4.7 79.7 1.0 CA A:ARG1154 4.7 89.4 1.0 C A:CYS1158 4.8 77.7 1.0 C A:GLY1156 4.8 88.2 1.0 C A:GLN1157 4.8 86.9 1.0 CB A:ARG1154 4.9 88.6 1.0

C.Bian, W.Tempel, X.Chao, C.Bountra, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, J.Min. Crystal Structure of Mll in Complex with A Cpg Island To Be Published.