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Atomistry » Zinc » PDB 4ngs-4nu7 » 4npw » |
Zinc in PDB 4npw: Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine)Enzymatic activity of Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine)
All present enzymatic activity of Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine):
3.1.4.17; Protein crystallography data
The structure of Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine), PDB code: 4npw
was solved by
J.Pandit,
A.Evdomikov,
M.Mansour,
S.Simons,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4npw:
The structure of Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine) also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine)
(pdb code 4npw). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine), PDB code: 4npw: Zinc binding site 1 out of 1 in 4npwGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Crystal Structure of Human PDE1B Bound to Inhibitor 19A (7,8- Dimethoxy-N-[(2S)-1-(3-Methyl-1H-Pyrazol-5-Yl)Propan-2-Yl]Quinazolin- 4-Amine)
![]() Mono view ![]() Stereo pair view
Reference:
J.M.Humphrey,
E.X.Yang,
C.W.Am Ende,
E.P.Arnold,
J.L.Head,
S.Jenkinsonb,
L.A.Lebel,
S.Liras,
J.Pandit,
B.Samas,
F.Vajdos,
S.P.Simons,
A.Evdokimova,
M.Mansour,
F.S.Menniti.
Small-Molecule Phosphodiesterase Probes: Discovery of Potent and Selective Cns-Penetrable Quinazoline Inhibitors of PDE1 Medchemcomm 2014.
Page generated: Sun Oct 27 03:17:20 2024
ISSN: ESSN 2040-2511 DOI: 10.1039/C4MD00113C |
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