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Zinc in PDB 4mm3: Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde

Enzymatic activity of Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde

All present enzymatic activity of Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde:
3.4.19.12; 3.4.22.69;

Protein crystallography data

The structure of Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde, PDB code: 4mm3 was solved by A.D.Mesecar, K.Ratia, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.65 / 2.75
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 47.147, 47.147, 332.658, 90.00, 90.00, 120.00
R / Rfree (%) 18.7 / 27.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde (pdb code 4mm3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde, PDB code: 4mm3:

Zinc binding site 1 out of 1 in 4mm3

Go back to Zinc Binding Sites List in 4mm3
Zinc binding site 1 out of 1 in the Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Sars-Cov Papain-Like Protease Plpro in Complex with Ubiquitin Aldehyde within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn401

b:31.6
occ:1.00
 SG B:CYS193 1.9 48.0 1.0
SG B:CYS227 2.2 32.0 1.0
SG B:CYS225 2.3 21.4 1.0
SG B:CYS190 2.5 21.1 1.0
CB B:CYS227 2.9 22.6 1.0
CB B:CYS193 3.1 16.9 1.0
CB B:CYS225 3.1 21.0 1.0
N B:CYS227 3.6 21.6 1.0
CA B:CYS227 3.8 22.2 1.0
CB B:CYS190 4.0 24.9 1.0
N B:CYS193 4.0 36.3 1.0
CA B:CYS193 4.1 26.8 1.0
CA B:CYS225 4.4 20.1 1.0
N B:VAL226 4.4 29.9 1.0
C B:CYS225 4.5 23.8 1.0
C B:CYS227 4.5 28.0 1.0
NH1 B:ARG229 4.7 28.3 1.0
N B:GLY228 4.8 26.0 1.0
C B:VAL226 4.8 30.6 1.0
ND1 B:HIS192 4.9 39.2 1.0
CB B:HIS192 4.9 34.5 1.0
CB B:ARG229 4.9 19.5 1.0
N B:ARG229 5.0 19.4 1.0

Reference:

K.Ratia, A.Kilianski, Y.M.Baez-Santos, S.C.Baker, A.Mesecar. Structural Basis For the Ubiquitin-Linkage Specificity and Deisgylating Activity of Sars-Cov Papain-Like Protease. Plos Pathog. V. 10 04113 2014.
ISSN: ISSN 1553-7366
PubMed: 24854014
DOI: 10.1371/JOURNAL.PPAT.1004113
Page generated: Sun Oct 27 02:34:02 2024

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