Zinc in PDB 4kxb: Crystal Structure of Human Aminopeptidase A Complexed with Bestatin

All present enzymatic activity of Crystal Structure of Human Aminopeptidase A Complexed with Bestatin:
3.4.11.7;

The structure of Crystal Structure of Human Aminopeptidase A Complexed with Bestatin, PDB code: 4kxb was solved by Y.Yang, C.Liu, Y.Y.Lin, F.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.73 / 2.40
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	141.852, 141.852, 237.061, 90.00, 90.00, 120.00
R / Rfree (%)	17.1 / 25.2

The binding sites of Zinc atom in the Crystal Structure of Human Aminopeptidase A Complexed with Bestatin (pdb code 4kxb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Aminopeptidase A Complexed with Bestatin, PDB code: 4kxb:

Zinc binding site 1 out of 1 in the Crystal Structure of Human Aminopeptidase A Complexed with Bestatin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Aminopeptidase A Complexed with Bestatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:74.2 occ:1.00 OE1 A:GLU416 2.0 60.6 1.0 NE2 A:HIS397 2.1 62.5 1.0 O2 A:BES1017 2.2 79.8 1.0 NE2 A:HIS393 2.2 58.2 1.0 O3 A:BES1017 2.9 73.6 1.0 CD A:GLU416 3.0 64.8 1.0 CD2 A:HIS393 3.0 54.4 1.0 CD2 A:HIS397 3.0 62.5 1.0 CE1 A:HIS397 3.1 63.0 1.0 C2 A:BES1017 3.2 76.1 1.0 OE2 A:GLU416 3.2 74.1 1.0 C3 A:BES1017 3.3 78.1 1.0 CE1 A:HIS393 3.3 56.2 1.0 C1 A:BES1017 3.9 62.4 1.0 N2 A:BES1017 4.0 72.5 1.0 CE2 A:TYR479 4.0 49.6 1.0 OH A:TYR479 4.2 67.3 1.0 CG A:HIS397 4.2 64.1 1.0 ND1 A:HIS397 4.2 65.6 1.0 CG A:HIS393 4.2 52.3 1.0 CB A:ALA419 4.2 57.7 1.0 ND1 A:HIS393 4.3 55.0 1.0 CG A:GLU416 4.3 66.0 1.0 N1 A:BES1017 4.4 77.7 1.0 CZ A:TYR479 4.5 55.6 1.0 OE2 A:GLU394 4.5 54.8 1.0 OE1 A:GLU394 4.5 69.4 1.0 CA A:GLU416 4.6 61.0 1.0 OE1 A:GLU360 4.7 66.9 1.0 CB A:GLU416 4.7 60.3 1.0 OE2 A:GLU360 4.9 63.0 1.0 CD A:GLU394 4.9 57.3 1.0 CD A:GLU360 4.9 61.9 1.0

Y.Yang, C.Liu, Y.L.Lin, F.Li. Structural Insights Into Central Hypertension Regulation By Human Aminopeptidase A. J.Biol.Chem. V. 288 25638 2013.
ISSN: ISSN 0021-9258
PubMed: 23888046
DOI: 10.1074/JBC.M113.494955