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Zinc in PDB 4kf9: Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site

Enzymatic activity of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site

All present enzymatic activity of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site:
2.5.1.18;

Protein crystallography data

The structure of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site, PDB code: 4kf9 was solved by M.W.Vetting, R.Toro, R.Bhosle, N.F.Al Obaidi, L.L.Morisco, S.R.Wasserman, S.Sojitra, M.Stead, E.Washington, A.Scott Glenn, S.Chowdhury, B.Evans, J.Hammonds, B.Hillerich, J.Love, R.D.Seidel, H.J.Imker, J.A.Gerlt, R.N.Armstrong, S.C.Almo, Enzyme Function Initiative (Efi), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.29 / 2.30
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 111.527, 111.527, 98.977, 90.00, 90.00, 120.00
R / Rfree (%) 15.9 / 18.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site (pdb code 4kf9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site, PDB code: 4kf9:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 4kf9

Go back to Zinc Binding Sites List in 4kf9
Zinc binding site 1 out of 4 in the Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:29.8
occ:1.00
 O A:ACT407 1.8 39.1 1.0
NE2 A:HIS224 2.1 30.0 1.0
OE2 A:GLU18 2.2 27.2 1.0
OE1 A:GLU18 2.2 28.6 1.0
OXT A:ACT407 2.5 40.7 1.0
C A:ACT407 2.5 33.9 1.0
CD A:GLU18 2.5 25.5 1.0
CD2 A:HIS224 3.0 25.0 1.0
CE1 A:HIS224 3.1 31.2 1.0
NE A:ARG21 3.9 24.6 1.0
CH3 A:ACT407 4.0 34.6 1.0
NH2 A:ARG21 4.1 18.6 1.0
CG A:GLU18 4.1 27.1 1.0
CG A:HIS224 4.2 29.5 1.0
ND1 A:HIS224 4.2 28.6 1.0
O A:HOH560 4.2 29.2 1.0
CZ A:ARG21 4.5 23.2 1.0
CZ2 A:TRP194 4.7 22.7 1.0
NE1 A:TRP194 4.8 24.2 1.0
O A:HOH604 4.8 31.1 1.0
CB A:GLU18 4.9 20.3 1.0
CD A:ARG21 5.0 21.2 1.0

Zinc binding site 2 out of 4 in 4kf9

Go back to Zinc Binding Sites List in 4kf9
Zinc binding site 2 out of 4 in the Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn402

b:31.3
occ:1.00
 O A:ACT408 2.0 35.1 1.0
OXT A:ACT406 2.1 26.9 1.0
O A:HOH501 2.1 43.9 1.0
SG2 A:GSH405 2.3 25.0 1.0
C A:ACT406 2.8 27.6 1.0
C A:ACT408 3.0 36.5 1.0
CB2 A:GSH405 3.1 23.2 1.0
CH3 A:ACT406 3.1 26.0 1.0
CH3 A:ACT408 3.3 32.0 1.0
CA2 A:GSH405 3.7 25.5 1.0
CD A:PRO15 3.7 18.0 1.0
OH A:TYR11 3.9 29.5 1.0
O A:ACT406 4.0 31.9 1.0
OXT A:ACT408 4.1 47.7 1.0
CG A:PRO15 4.4 20.2 1.0
NH2 A:ARG137 4.4 25.0 1.0
N3 A:GSH405 4.4 24.5 1.0
C2 A:GSH405 4.5 22.2 1.0
CA A:SER14 4.6 20.7 1.0
CZ A:PHE105 4.7 20.9 1.0
N A:PRO15 4.7 21.7 1.0
OG A:SER14 4.7 23.0 1.0
CB A:SER14 4.8 23.6 1.0
N2 A:GSH405 4.9 21.3 1.0
CZ A:TYR11 4.9 27.8 1.0

Zinc binding site 3 out of 4 in 4kf9

Go back to Zinc Binding Sites List in 4kf9
Zinc binding site 3 out of 4 in the Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn403

b:0.7
occ:1.00
 NE2 A:HIS79 2.1 66.3 1.0
CE1 A:HIS79 3.0 62.9 1.0
CD2 A:HIS79 3.1 62.5 1.0
OE1 A:GLN29 3.8 53.1 1.0
ND1 A:HIS79 4.1 60.1 1.0
CG A:HIS79 4.2 56.2 1.0
NE2 A:GLN29 4.4 44.5 1.0
CG2 A:ILE78 4.5 39.1 1.0
CD A:GLN29 4.5 48.5 1.0
O A:HOH668 4.9 58.1 1.0

Zinc binding site 4 out of 4 in 4kf9

Go back to Zinc Binding Sites List in 4kf9
Zinc binding site 4 out of 4 in the Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn404

b:0.7
occ:1.00
 OE1 A:GLU234 2.1 55.4 1.0
CD A:GLU234 3.0 46.1 1.0
OE2 A:GLU234 3.2 42.1 1.0
CG A:GLU234 4.4 41.5 1.0
CG2 A:THR231 4.8 24.2 1.0
O A:HOH691 4.9 48.4 1.0

Reference:

M.W.Vetting, R.Toro, R.Bhosle, N.F.Al Obaidi, L.L.Morisco, S.R.Wasserman, S.Sojitra, M.Stead, E.Washington, A.Scott Glenn, S.Chowdhury, B.Evans, J.Hammonds, B.Hillerich, J.Love, R.D.Seidel, H.J.Imker, J.A.Gerlt, R.N.Armstrong, S.C.Almo, Enzyme Function Initiative (Efi). Crystal Structure of A Glutathione Transferase Family Member From Ralstonia Solanacearum, Target Efi-501780, with Bound Gsh Coordinated to A Zinc Ion, Ordered Active Site To Be Published.
Page generated: Sun Oct 27 01:10:19 2024

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