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Atomistry » Zinc » PDB 4hwt-4i7h » 4hyf | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4hwt-4i7h » 4hyf » |
Zinc in PDB 4hyf: Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 InhibitorEnzymatic activity of Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor
All present enzymatic activity of Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor:
2.4.2.30; Protein crystallography data
The structure of Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor, PDB code: 4hyf
was solved by
H.Perdreau,
B.Ekblad,
A.Voronkov,
D.D.Holsworth,
J.Waaler,
G.Drewes,
H.Schueler,
S.Krauss,
J.P.Morth,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4hyf:
The structure of Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor
(pdb code 4hyf). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor, PDB code: 4hyf: Jump to Zinc binding site number: 1; 2; 3; Zinc binding site 1 out of 3 in 4hyfGo back to![]() ![]()
Zinc binding site 1 out
of 3 in the Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 3 in 4hyfGo back to![]() ![]()
Zinc binding site 2 out
of 3 in the Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor
![]() Mono view ![]() Stereo pair view
Zinc binding site 3 out of 3 in 4hyfGo back to![]() ![]()
Zinc binding site 3 out
of 3 in the Structural Basis and Sar For Od 270, A Lead Stage 1,2,4-Triazole Based Specific TANKYRASE1/2 Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
A.Voronkov,
D.D.Holsworth,
J.Waaler,
S.R.Wilson,
B.Ekblad,
H.Perdreau-Dahl,
H.Dinh,
G.Drewes,
C.Hopf,
J.P.Morth,
S.Krauss.
Structural Basis and Sar For G007-Lk, A Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor. J.Med.Chem. V. 56 3012 2013.
Page generated: Sun Oct 27 00:22:44 2024
ISSN: ISSN 0022-2623 PubMed: 23473363 DOI: 10.1021/JM4000566 |
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