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Zinc in PDB 4gv6: Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production

Protein crystallography data

The structure of Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production, PDB code: 4gv6 was solved by X.Jiang, Q.Huang, W.Wang, H.Dong, H.Ly, Y.Liang, C.Dong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.16 / 1.98
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 46.510, 46.510, 208.650, 90.00, 90.00, 90.00
R / Rfree (%) 18.8 / 22.9

Other elements in 4gv6:

The structure of Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production (pdb code 4gv6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production, PDB code: 4gv6:

Zinc binding site 1 out of 1 in 4gv6

Go back to Zinc Binding Sites List in 4gv6
Zinc binding site 1 out of 1 in the Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structures of Lassa and Tacaribe Viral Nucleoproteins with or Without 5 Triphosphate Dsrna Substrate Reveal A Unique 3 -5 Exoribonuclease Mechanism to Suppress Type I Interferon Production within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn601

b:2.6
occ:1.00
NE2 A:HIS509 2.0 7.3 1.0
OE2 A:GLU399 2.0 4.2 1.0
SG A:CYS529 2.2 3.9 1.0
SG A:CYS506 2.2 5.3 1.0
CD2 A:HIS509 2.8 7.2 1.0
CD A:GLU399 3.0 4.8 1.0
CE1 A:HIS509 3.2 7.2 1.0
CB A:CYS529 3.2 4.1 1.0
CB A:CYS506 3.3 6.1 1.0
OE1 A:GLU399 3.3 4.5 1.0
CA A:CYS529 3.8 4.3 1.0
NE2 A:HIS412 3.9 7.4 1.0
CG A:HIS509 4.1 7.9 1.0
ND1 A:HIS509 4.2 6.9 1.0
CE1 A:HIS412 4.2 7.7 1.0
N A:ALA530 4.3 3.1 1.0
CG A:GLU399 4.4 5.0 1.0
C A:CYS529 4.4 4.0 1.0
CE2 A:PHE414 4.5 15.8 1.0
CZ A:PHE414 4.6 16.8 1.0
CA A:CYS506 4.7 7.7 1.0
N A:LEU531 4.8 2.9 1.0
CB A:MET508 4.8 15.4 1.0

Reference:

X.Jiang, Q.Huang, W.Wang, H.Dong, H.Ly, Y.Liang, C.Dong. Structures of Arenaviral Nucleoproteins with Triphosphate Dsrna Reveal A Unique Mechanism of Immune Suppression. J.Biol.Chem. V. 288 16949 2013.
ISSN: ISSN 0021-9258
PubMed: 23615902
DOI: 10.1074/JBC.M112.420521
Page generated: Sat Oct 26 23:38:27 2024

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