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Zinc in PDB 4gh1: Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor

Enzymatic activity of Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor

All present enzymatic activity of Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor, PDB code: 4gh1 was solved by F.Immekus, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.45
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.879, 64.857, 71.138, 90.00, 96.37, 90.00
R / Rfree (%) 17.4 / 20.6

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor (pdb code 4gh1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor, PDB code: 4gh1:

Zinc binding site 1 out of 1 in 4gh1

Go back to Zinc Binding Sites List in 4gh1
Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase in Complex with Morpholine Substituted Lin-Benzohypoxanthine Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:13.1
occ:1.00
 ND1 A:HIS349 2.1 11.8 1.0
SG A:CYS318 2.3 14.9 1.0
SG A:CYS323 2.3 13.3 1.0
SG A:CYS320 2.3 12.9 1.0
CE1 A:HIS349 2.9 11.2 1.0
CB A:CYS323 3.3 12.7 1.0
CG A:HIS349 3.3 10.2 1.0
CB A:CYS318 3.3 13.6 1.0
CB A:CYS320 3.4 9.7 1.0
CB A:HIS349 3.8 11.3 1.0
N A:CYS323 3.9 12.9 1.0
CA A:HIS349 4.1 10.3 1.0
N A:CYS320 4.1 13.7 1.0
NE2 A:HIS349 4.1 11.8 1.0
CA A:CYS323 4.2 12.4 1.0
CA A:CYS320 4.2 13.8 1.0
CD2 A:HIS349 4.3 13.3 1.0
O A:HIS349 4.6 11.7 1.0
CA A:CYS318 4.6 14.1 1.0
O A:CYS320 4.6 13.1 1.0
C A:CYS320 4.7 13.4 1.0
C A:CYS318 4.7 14.2 1.0
C A:HIS349 4.8 12.2 1.0
CB A:VAL322 4.8 10.8 1.0
O A:CYS318 4.9 17.0 1.0
C A:VAL322 4.9 13.7 1.0

Reference:

F.Immekus, L.J.Barandun, F.Diederich, G.Klebe. Two-Armed Benzopurine Inhibitors of Tgt To Be Published.
Page generated: Sat Oct 26 23:18:37 2024

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