Zinc in PDB 4fwu: Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4

All present enzymatic activity of Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4:
2.3.2.5;

The structure of Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4, PDB code: 4fwu was solved by P.Kolenko, B.Koch, M.T.Stubbs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.00 / 2.00
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	122.344, 122.344, 72.736, 90.00, 90.00, 90.00
R / Rfree (%)	16.6 / 20.8

The binding sites of Zinc atom in the Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4 (pdb code 4fwu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4, PDB code: 4fwu:

Zinc binding site 1 out of 1 in the Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:15.7 occ:1.00 OE2 A:GLU171 1.9 13.6 1.0 OD2 A:ASP131 2.0 14.9 1.0 NE2 A:HIS297 2.0 18.0 1.0 O A:HOH843 2.2 23.0 1.0 CD A:GLU171 2.6 14.6 1.0 CG A:ASP131 2.8 15.2 1.0 OE1 A:GLU171 2.8 14.0 1.0 CD2 A:HIS297 2.9 17.1 1.0 OD1 A:ASP131 2.9 14.9 1.0 CE1 A:HIS297 3.1 17.2 1.0 CG A:GLU171 4.1 14.9 1.0 CG A:HIS297 4.1 17.0 1.0 O A:HOH508 4.2 12.4 1.0 ND1 A:HIS297 4.2 16.7 1.0 CB A:ASP131 4.2 14.3 1.0 OE1 A:GLU170 4.3 16.8 1.0 NE1 A:TRP296 4.3 17.2 1.0 O2 A:EDO405 4.3 23.8 1.0 O A:HOH505 4.6 13.5 1.0 NE2 A:HIS114 4.6 15.4 1.0 CD A:LYS118 4.8 18.0 1.0 CD2 A:LEU219 4.8 11.6 1.0 CE2 A:TRP296 4.9 17.1 1.0 CD1 A:TRP296 4.9 17.7 1.0

P.Kolenko, B.Koch, J.U.Rahfeld, S.Schilling, H.U.Demuth, M.T.Stubbs. Structure of Glutaminyl Cyclase From Drosophila Melanogaster in Space Group I4. Acta Crystallogr.,Sect.F V. 69 358 2013.
ISSN: ESSN 1744-3091
PubMed: 23545638
DOI: 10.1107/S1744309113005575