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Atomistry » Zinc » PDB 4fkh-4fvu » 4fm8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4fkh-4fvu » 4fm8 » |
Zinc in PDB 4fm8: Crystal Structure of Bace with Compound 12AEnzymatic activity of Crystal Structure of Bace with Compound 12A
All present enzymatic activity of Crystal Structure of Bace with Compound 12A:
3.4.23.46; Protein crystallography data
The structure of Crystal Structure of Bace with Compound 12A, PDB code: 4fm8
was solved by
F.F.Vajdos,
A.H.Varghese,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4fm8:
The structure of Crystal Structure of Bace with Compound 12A also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Bace with Compound 12A
(pdb code 4fm8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Bace with Compound 12A, PDB code: 4fm8: Zinc binding site 1 out of 1 in 4fm8Go back to![]() ![]()
Zinc binding site 1 out
of 1 in the Crystal Structure of Bace with Compound 12A
![]() Mono view ![]() Stereo pair view
Reference:
M.A.Brodney,
G.Barreiro,
K.Ogilvie,
E.Hajos-Korcsok,
J.Murray,
F.Vajdos,
C.Ambroise,
C.Christoffersen,
K.Fisher,
L.Lanyon,
J.Liu,
C.E.Nolan,
J.M.Withka,
K.A.Borzilleri,
I.Efremov,
C.E.Oborski,
A.Varghese,
B.T.O'neill.
Spirocyclic Sulfamides As Beta-Secretase 1 (Bace-1) Inhibitors For the Treatment of Alzheimer'S Disease: Utilization of Structure Based Drug Design, Watermap, and Cns Penetration Studies to Identify Centrally Efficacious Inhibitors. J.Med.Chem. V. 55 9224 2012.
Page generated: Sat Oct 26 22:49:37 2024
ISSN: ISSN 0022-2623 PubMed: 22984865 DOI: 10.1021/JM3009426 |
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