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Zinc in PDB 4fbe: Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster

Enzymatic activity of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster

All present enzymatic activity of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster:
2.3.2.5;

Protein crystallography data

The structure of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster, PDB code: 4fbe was solved by P.Kolenko, B.Koch, D.Ruiz-Carilo, M.T.Stubbs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 71.66 / 1.88
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 45.928, 46.436, 74.150, 84.93, 75.17, 74.47
R / Rfree (%) 17.1 / 22.3

Other elements in 4fbe:

The structure of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster (pdb code 4fbe). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster, PDB code: 4fbe:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4fbe

Go back to Zinc Binding Sites List in 4fbe
Zinc binding site 1 out of 2 in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn403

b:15.6
occ:1.00
 OD2 A:ASP153 1.9 16.3 1.0
OE2 A:GLU191 2.0 13.5 1.0
NE2 A:HIS318 2.1 15.7 1.0
NAM A:PBD401 2.1 16.8 1.0
CG A:ASP153 2.7 16.3 1.0
CD A:GLU191 2.7 13.9 1.0
OE1 A:GLU191 2.8 14.4 1.0
OD1 A:ASP153 2.9 17.0 1.0
CAH A:PBD401 2.9 17.2 1.0
CD2 A:HIS318 3.0 16.5 1.0
CE1 A:HIS318 3.2 16.1 1.0
CAD A:PBD401 3.3 17.1 1.0
NE1 A:TRP317 3.9 18.3 1.0
NAV A:PBD401 4.1 17.1 1.0
CB A:ASP153 4.1 16.1 1.0
O A:HOH508 4.1 9.1 1.0
CG A:GLU191 4.2 13.9 1.0
CG A:HIS318 4.2 16.7 1.0
ND1 A:HIS318 4.3 16.6 1.0
CAG A:PBD401 4.3 17.8 1.0
OE1 A:GLU190 4.3 12.8 1.0
CE2 A:TRP317 4.6 18.9 1.0
CD1 A:TRP317 4.7 18.6 1.0
NE2 A:HIS137 4.8 10.9 1.0
CZ2 A:TRP317 4.8 19.4 1.0
O A:HOH529 4.8 11.4 1.0
O A:ASP153 4.9 15.0 1.0
CD A:LYS141 4.9 15.5 1.0
CD2 A:LEU229 4.9 13.8 1.0

Zinc binding site 2 out of 2 in 4fbe

Go back to Zinc Binding Sites List in 4fbe
Zinc binding site 2 out of 2 in the Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the C136A/C164A Variant of Mitochondrial Isoform of Glutaminyl Cyclase From Drosophila Melanogaster within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn401

b:12.6
occ:1.00
 OD2 B:ASP153 1.9 10.2 1.0
OE2 B:GLU191 1.9 11.2 1.0
NAM B:PBD402 2.0 16.8 1.0
NE2 B:HIS318 2.1 13.4 1.0
CD B:GLU191 2.7 11.5 1.0
CG B:ASP153 2.7 10.6 1.0
OE1 B:GLU191 2.8 11.0 1.0
OD1 B:ASP153 2.8 10.7 1.0
CAD B:PBD402 2.9 16.6 1.0
CAH B:PBD402 3.0 17.0 1.0
CD2 B:HIS318 3.0 13.0 1.0
CE1 B:HIS318 3.1 13.0 1.0
O B:HOH507 3.9 10.4 1.0
NE1 B:TRP317 4.0 13.6 1.0
CAG B:PBD402 4.1 16.9 1.0
NAV B:PBD402 4.1 17.0 1.0
CG B:GLU191 4.1 10.8 1.0
CB B:ASP153 4.1 10.6 1.0
OE1 B:GLU190 4.1 13.2 1.0
CG B:HIS318 4.2 13.1 1.0
ND1 B:HIS318 4.2 12.8 1.0
O B:HOH504 4.6 10.6 1.0
NE2 B:HIS137 4.6 9.1 1.0
CE2 B:TRP317 4.6 13.3 1.0
CD1 B:TRP317 4.7 13.9 1.0
CD2 B:LEU229 4.7 11.0 1.0
CZ2 B:TRP317 4.8 13.7 1.0
O B:HOH506 4.9 12.8 1.0
O B:ASP153 4.9 11.9 1.0
CE1 B:HIS137 4.9 9.1 1.0
OE2 B:GLU190 4.9 13.6 1.0
CD B:GLU190 4.9 12.8 1.0
CD B:LYS141 5.0 10.8 1.0

Reference:

B.Koch, P.Kolenko, M.Buchholz, D.Ruiz Carrillo, C.Parthier, M.Wermann, J.U.Rahfeld, G.Reuter, S.Schilling, M.T.Stubbs, H.U.Demuth. Crystal Structures of Glutaminyl Cyclases (Qcs) From Drosophila Melanogaster Reveal Active Site Conservation Between Insect and Mammalian Qcs. Biochemistry V. 51 7383 2012.
ISSN: ISSN 0006-2960
PubMed: 22897232
DOI: 10.1021/BI300687G
Page generated: Sat Oct 26 22:21:28 2024

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