Zinc in PDB 4f7o: Crystal Structure of CSN5

The structure of Crystal Structure of CSN5, PDB code: 4f7o was solved by A.Echalier, M.Birol, F.Hoh, C.Dumas, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.00 / 2.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	161.734, 46.505, 71.261, 90.00, 100.27, 90.00
R / Rfree (%)	21.6 / 27.4

The binding sites of Zinc atom in the Crystal Structure of CSN5 (pdb code 4f7o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of CSN5, PDB code: 4f7o:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of CSN5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of CSN5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:27.6 occ:1.00 NE2 A:HIS140 2.0 32.8 1.0 NE2 A:HIS138 2.1 11.5 1.0 O A:HOH401 2.1 47.8 1.0 OD2 A:ASP151 2.1 32.3 1.0 OD1 A:ASP151 2.3 32.9 1.0 CG A:ASP151 2.5 30.2 1.0 CE1 A:HIS140 2.8 34.8 1.0 CD2 A:HIS138 3.0 7.6 1.0 CE1 A:HIS138 3.1 16.0 1.0 CD2 A:HIS140 3.2 28.3 1.0 OG A:SER148 3.4 20.5 1.0 ND1 A:HIS140 4.0 27.5 1.0 CB A:ASP151 4.0 35.7 1.0 CB A:SER148 4.1 19.2 1.0 CG A:HIS140 4.2 28.0 1.0 CG A:HIS138 4.2 14.7 1.0 ND1 A:HIS138 4.2 21.8 1.0 NH1 A:ARG106 4.3 52.7 1.0 N A:SER148 4.4 18.0 1.0 O A:TRP146 4.6 15.7 1.0 NH2 A:ARG106 4.7 48.7 1.0 CA A:SER148 4.9 21.4 1.0 CZ A:ARG106 5.0 48.9 1.0 CA A:ASP151 5.0 34.4 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of CSN5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of CSN5 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:34.8 occ:1.00 OD2 B:ASP151 2.0 40.3 1.0 NE2 B:HIS140 2.0 37.2 1.0 NE2 B:HIS138 2.1 9.6 1.0 O B:HOH401 2.1 18.4 1.0 CG B:ASP151 2.7 36.9 1.0 OD1 B:ASP151 2.8 26.8 1.0 CE1 B:HIS138 2.9 19.8 1.0 CE1 B:HIS140 2.9 34.5 1.0 CD2 B:HIS140 3.1 29.1 1.0 CD2 B:HIS138 3.2 17.9 1.0 OG B:SER148 3.5 25.9 1.0 CB B:SER148 3.9 29.0 1.0 ND1 B:HIS138 4.1 28.0 1.0 ND1 B:HIS140 4.1 31.8 1.0 NH2 B:ARG106 4.2 80.7 1.0 CB B:ASP151 4.2 40.8 1.0 CG B:HIS140 4.2 35.1 1.0 CG B:HIS138 4.3 22.6 1.0 N B:SER148 4.3 30.7 1.0 O B:TRP146 4.6 33.5 1.0 CA B:SER148 4.8 30.6 1.0 NH1 B:ARG106 4.8 65.8 1.0 CZ B:ARG106 5.0 74.2 1.0

A.Echalier, Y.Pan, M.Birol, N.Tavernier, L.Pintard, F.Hoh, C.Ebel, N.Galophe, F.X.Claret, C.Dumas. Insights Into the Regulation of the Human COP9 Signalosome Catalytic Subunit, CSN5/JAB1. Proc.Natl.Acad.Sci.Usa V. 110 1273 2013.
ISSN: ISSN 0027-8424
PubMed: 23288897
DOI: 10.1073/PNAS.1209345110