Atomistry » Zinc » PDB 4cz1-4d9q » 4d30
Atomistry »
  Zinc »
    PDB 4cz1-4d9q »
      4d30 »

Zinc in PDB 4d30: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine

Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine

All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine, PDB code: 4d30 was solved by H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.429 / 1.96
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.840, 111.000, 164.000, 90.00, 90.00, 90.00
R / Rfree (%) 18.09 / 23.47

Other elements in 4d30:

The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine also contains other interesting chemical elements:

Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine (pdb code 4d30). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine, PDB code: 4d30:

Zinc binding site 1 out of 1 in 4d30

Go back to Zinc Binding Sites List in 4d30
Zinc binding site 1 out of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with N-2-(2-(1H-Imidazol-1-Yl)Pyrimidin-4-Yl) Ethyl-3-(Pyridin-3-Yl)Propan-1-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1717

b:24.9
occ:1.00
 SG B:CYS326 2.3 24.0 1.0
SG A:CYS326 2.3 32.5 1.0
SG A:CYS331 2.4 24.3 1.0
SG B:CYS331 2.4 22.2 1.0
CB A:CYS331 3.2 25.4 1.0
CB B:CYS331 3.3 22.0 1.0
CB A:CYS326 3.4 21.0 1.0
CB B:CYS326 3.4 26.2 1.0
CA A:CYS331 3.6 32.5 1.0
CA B:CYS331 3.6 22.6 1.0
N A:MET332 3.9 32.1 1.0
N B:MET332 4.0 21.3 1.0
N A:GLY333 4.1 26.9 1.0
C A:CYS331 4.2 34.4 1.0
N B:GLY333 4.2 29.2 1.0
C B:CYS331 4.2 22.9 1.0
CA A:GLY333 4.5 24.8 1.0
CA B:GLY333 4.6 28.0 1.0
CA A:CYS326 4.8 35.1 1.0
CA B:CYS326 4.8 30.7 1.0
O A:HOH2010 4.8 39.2 1.0
N A:CYS331 4.9 34.5 1.0
N B:CYS331 4.9 30.9 1.0
C A:MET332 4.9 26.3 1.0

Reference:

P.Mukherjee, H.Li, I.F.Sevrioukova, G.Chreifi, P.Martasek, L.J.Roman, T.L.Poulos, R.B.Silverman. Novel 2,4-Disubstituted Pyrimidines As Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem. 2014.
ISSN: ESSN 1520-4804
PubMed: 25489882
DOI: 10.1021/JM501719E
Page generated: Sat Oct 26 21:17:50 2024

Last articles

Mn in 3E6V
Mn in 3E6K
Mn in 3E44
Mn in 3DYS
Mn in 3DW9
Mn in 3DYL
Mn in 3DY8
Mn in 3DW8
Mn in 3DX5
Mn in 3DT7
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy