Atomistry » Zinc » PDB 4csz-4cyk » 4cx3
Atomistry »
  Zinc »
    PDB 4csz-4cyk »
      4cx3 »

Zinc in PDB 4cx3: Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine

Enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine

All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine:
1.14.13.39;

Protein crystallography data

The structure of Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine, PDB code: 4cx3 was solved by H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.89 / 1.97
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.925, 110.680, 164.333, 90.00, 90.00, 90.00
R / Rfree (%) 17.495 / 20.949

Other elements in 4cx3:

The structure of Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine also contains other interesting chemical elements:

Iron (Fe) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine (pdb code 4cx3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine, PDB code: 4cx3:

Zinc binding site 1 out of 1 in 4cx3

Go back to Zinc Binding Sites List in 4cx3
Zinc binding site 1 out of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Rat Neuronal Nitric Oxide Synthase M336V D597N Mutant Heme Domain in Complex with 4-Methyl-6-(((3R,4R)-4-( (5-(Pyridin-2-Yl)Pentyl)Oxy)Pyrrolidin-3-Yl)Methyl)Pyridin- 2-Amine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn900

b:29.7
occ:1.00
 SG A:CYS326 2.3 37.2 1.0
SG A:CYS331 2.4 31.6 1.0
SG B:CYS331 2.4 30.7 1.0
SG B:CYS326 2.4 34.6 1.0
CB B:CYS331 3.3 34.8 1.0
CB A:CYS331 3.3 31.8 1.0
CB A:CYS326 3.4 42.2 1.0
CB B:CYS326 3.4 40.8 1.0
CA B:CYS331 3.6 34.5 1.0
CA A:CYS331 3.6 34.2 1.0
N A:MET332 4.0 32.8 1.0
N B:MET332 4.1 32.0 1.0
N A:GLY333 4.1 31.6 1.0
N B:GLY333 4.1 30.6 1.0
C A:CYS331 4.2 33.4 1.0
C B:CYS331 4.3 33.6 1.0
CA A:GLY333 4.5 29.8 1.0
CA B:GLY333 4.6 29.7 1.0
CA A:CYS326 4.7 44.3 1.0
CA B:CYS326 4.8 41.9 1.0
N B:CYS331 4.9 36.8 1.0
N A:CYS331 4.9 36.0 1.0
C A:MET332 4.9 32.0 1.0
O A:HOH2008 4.9 36.0 1.0
O B:ILE330 5.0 39.4 1.0

Reference:

H.Li, J.Jamal, S.L.Delker, C.Plaza, H.Ji, Q.Jing, H.Huang, S.Kang, R.B.Silverman, T.L.Poulos. Mobility of A Conserved Tyrosine Residue Controls Isoform- Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases. Biochemistry V. 53 5272 2014.
ISSN: ISSN 0006-2960
PubMed: 25089924
DOI: 10.1021/BI500561H
Page generated: Sat Oct 26 21:10:45 2024

Last articles

Mo in 4C80
Mo in 4DMR
Mo in 4BVP
Mo in 3ZX0
Mo in 4BRF
Mo in 4C7Z
Mo in 4C7Y
Mo in 3ZYV
Mo in 4AAY
Mo in 4B1A
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy