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Zinc in PDB 4cdg: Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody

Enzymatic activity of Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody

All present enzymatic activity of Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody:
3.6.4.12;

Protein crystallography data

The structure of Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody, PDB code: 4cdg was solved by J.A.Newman, P.Savitsky, C.K.Allerston, A.C.W.Pike, E.Pardon, J.Steyaert, C.H.Arrowsmith, F.Von Delft, C.Bountra, A.Edwards, O.Gileadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.881 / 2.79
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 59.666, 88.425, 95.120, 69.39, 89.84, 77.07
R / Rfree (%) 20.56 / 24.55

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody (pdb code 4cdg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody, PDB code: 4cdg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4cdg

Go back to Zinc Binding Sites List in 4cdg
Zinc binding site 1 out of 2 in the Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1643

b:54.1
occ:1.00
SG A:CYS1055 2.3 45.2 1.0
SG A:CYS1036 2.4 59.1 1.0
SG A:CYS1063 2.4 59.7 1.0
SG A:CYS1066 2.4 63.6 1.0
CB A:CYS1055 3.2 53.8 1.0
CB A:CYS1066 3.3 47.0 1.0
CB A:CYS1036 3.3 53.0 1.0
CB A:CYS1063 3.6 45.7 1.0
CA A:CYS1036 3.7 56.2 1.0
N A:CYS1063 3.9 42.5 1.0
N A:ARG1037 4.1 54.0 1.0
C A:CYS1036 4.3 61.7 1.0
CA A:CYS1063 4.3 47.8 1.0
N A:CYS1066 4.4 50.2 1.0
CA A:CYS1066 4.5 50.2 1.0
CG A:ARG1038 4.6 40.7 1.0
CD A:ARG1038 4.6 41.8 1.0
CA A:CYS1055 4.6 53.5 1.0
N A:ARG1038 4.7 47.1 1.0
N A:CYS1055 4.9 54.5 1.0
O A:CYS1063 4.9 60.1 1.0
C A:CYS1063 4.9 55.4 1.0
CB A:ARG1038 5.0 40.8 1.0
NE A:ARG1038 5.0 47.2 1.0
N A:CYS1036 5.0 50.4 1.0

Zinc binding site 2 out of 2 in 4cdg

Go back to Zinc Binding Sites List in 4cdg
Zinc binding site 2 out of 2 in the Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1643

b:55.4
occ:1.00
SG B:CYS1055 2.3 49.9 1.0
SG B:CYS1063 2.4 55.8 1.0
SG B:CYS1066 2.4 57.5 1.0
SG B:CYS1036 2.4 61.1 1.0
CB B:CYS1055 3.2 53.9 1.0
CB B:CYS1066 3.3 50.7 1.0
CB B:CYS1036 3.3 58.5 1.0
CB B:CYS1063 3.6 52.3 1.0
CA B:CYS1036 3.7 56.6 1.0
N B:CYS1063 4.0 42.2 1.0
N B:ARG1037 4.1 56.8 1.0
C B:CYS1036 4.3 55.9 1.0
CA B:CYS1063 4.4 48.7 1.0
N B:CYS1066 4.4 40.5 1.0
CA B:CYS1066 4.4 49.5 1.0
CA B:CYS1055 4.5 59.3 1.0
CG B:ARG1038 4.6 37.1 1.0
CD B:ARG1038 4.7 36.8 1.0
N B:ARG1038 4.7 45.0 1.0
N B:CYS1055 4.8 59.4 1.0
O B:CYS1063 5.0 57.7 1.0
N B:CYS1036 5.0 62.4 1.0
C B:CYS1063 5.0 52.4 1.0

Reference:

J.A.Newman, P.Savitsky, C.K.Allerston, A.C.W.Pike, E.Pardon, J.Steyaert, C.H.Arrowsmith, F.Von Delft, C.Bountra, A.Edwards, O.Gileadi. Crystal Structure of the Bloom'S Syndrome Helicase Blm in Complex with Nanobody To Be Published.
Page generated: Sat Oct 26 20:45:33 2024

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