|
Atomistry » Zinc » PDB 4b52-4bj9 » 4bcw | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4b52-4bj9 » 4bcw » |
Zinc in PDB 4bcw: Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic AcidEnzymatic activity of Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid
All present enzymatic activity of Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid, PDB code: 4bcw
was solved by
K.Tars,
J.Leitans,
A.Kazaks,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4bcw:
The structure of Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid
(pdb code 4bcw). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid, PDB code: 4bcw: Zinc binding site 1 out of 1 in 4bcwGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Carbonic Anhydrase IX Mimic in Complex with (E)-2-(5-Bromo-2- Hydroxyphenyl)Ethenesulfonic Acid
![]() Mono view ![]() Stereo pair view
Reference:
K.Tars,
D.Vullo,
A.Kazaks,
J.Leitans,
A.Lends,
A.Grandane,
R.Zalubovskis,
A.Scozzafava,
C.T.Supuran.
Sulfocoumarins (1,2-Benzoxathiine-2,2-Dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases. J.Med.Chem. V. 56 293 2013.
Page generated: Sat Oct 26 19:38:45 2024
ISSN: ISSN 0022-2623 PubMed: 23241068 DOI: 10.1021/JM301625S |
Last articlesNa in 5MIMNa in 5MJ3 Na in 5MIG Na in 5MIE Na in 5MFT Na in 5MID Na in 5MIC Na in 5MIB Na in 5MIA Na in 5MI2 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |