Zinc in PDB 4b7y: Crystal Structure of the MSL1-MSL2 Complex

The structure of Crystal Structure of the MSL1-MSL2 Complex, PDB code: 4b7y was solved by E.Hallacli, M.Lipp, P.Georgiev, C.Spielman, S.Cusack, A.Akhtar, J.Kadlec, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	87.46 / 3.25
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	100.990, 100.990, 88.650, 90.00, 90.00, 120.00
R / Rfree (%)	24.448 / 25.966

The binding sites of Zinc atom in the Crystal Structure of the MSL1-MSL2 Complex (pdb code 4b7y). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of the MSL1-MSL2 Complex, PDB code: 4b7y:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of the MSL1-MSL2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the MSL1-MSL2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn501 b:57.5 occ:1.00 SG C:CYS44 2.2 55.1 1.0 SG C:CYS47 2.2 59.8 1.0 SG C:CYS67 2.6 57.1 1.0 CB C:CYS47 2.6 55.0 1.0 SG C:CYS70 2.7 66.7 1.0 CB C:CYS44 2.8 50.0 1.0 N C:CYS47 3.4 57.0 1.0 CA C:CYS47 3.5 56.4 1.0 CB C:CYS67 3.5 62.3 1.0 CB C:CYS70 3.9 68.7 1.0 N C:CYS67 4.0 58.7 1.0 CA C:CYS44 4.2 46.8 1.0 CA C:CYS67 4.4 61.5 1.0 C C:VAL46 4.5 58.8 1.0 C C:CYS44 4.6 47.8 1.0 O C:CYS44 4.7 47.6 1.0 C C:CYS47 4.8 53.4 1.0 CB C:VAL46 4.8 63.7 1.0 N C:VAL46 4.9 55.7 1.0 N C:GLY48 4.9 49.9 1.0 CA C:VAL46 5.0 59.6 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of the MSL1-MSL2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the MSL1-MSL2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn502 b:59.4 occ:1.00 SG C:CYS84 1.8 61.7 1.0 SG C:CYS81 2.1 62.6 1.0 ND1 C:HIS64 2.2 52.5 1.0 SG C:CYS62 2.4 58.6 1.0 CB C:CYS81 2.8 62.2 1.0 CE1 C:HIS64 2.8 51.9 1.0 CG C:HIS64 3.1 50.8 1.0 CB C:CYS84 3.2 67.9 1.0 CB C:CYS62 3.3 58.1 1.0 CB C:HIS64 3.6 51.5 1.0 N C:CYS84 3.6 72.5 1.0 NE2 C:HIS64 3.8 49.9 1.0 CA C:CYS84 3.8 71.8 1.0 CD2 C:HIS64 3.9 49.1 1.0 CA C:CYS81 4.2 66.2 1.0 O C:CYS62 4.5 48.9 1.0 C C:CYS81 4.5 71.1 1.0 CA C:CYS62 4.6 55.0 1.0 C C:TRP83 4.6 76.0 1.0 C C:CYS62 4.6 51.0 1.0 N C:HIS64 4.7 48.9 1.0 CE C:MET77 4.7 55.7 1.0 O C:CYS81 4.7 73.2 1.0 CB C:TRP83 4.8 73.1 1.0 CA C:HIS64 4.8 48.7 1.0 N C:TRP83 4.8 75.8 1.0 CA C:TRP83 5.0 76.6 1.0 CD1 C:TRP83 5.0 69.0 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of the MSL1-MSL2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the MSL1-MSL2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn501 b:76.9 occ:1.00 SG D:CYS44 2.3 75.8 1.0 SG D:CYS67 2.3 72.2 1.0 CB D:CYS47 2.4 75.2 1.0 SG D:CYS70 2.5 85.0 1.0 CB D:CYS44 3.0 70.2 1.0 CB D:CYS67 3.1 75.4 1.0 N D:CYS47 3.1 80.7 1.0 CA D:CYS47 3.2 79.1 1.0 SG D:CYS47 3.4 75.2 1.0 N D:CYS67 3.6 74.0 1.0 CB D:CYS70 3.8 88.6 1.0 CA D:CYS67 3.9 74.3 1.0 C D:VAL46 4.1 85.2 1.0 CA D:CYS44 4.5 68.5 1.0 C D:CYS47 4.6 78.0 1.0 CB D:VAL46 4.7 89.8 1.0 N D:VAL46 4.7 82.6 1.0 C D:VAL66 4.7 73.7 1.0 CA D:VAL46 4.7 86.9 1.0 C D:CYS44 4.9 71.9 1.0 CA D:VAL66 4.9 74.4 1.0 O D:VAL46 5.0 88.3 1.0 N D:GLY48 5.0 74.8 1.0 C D:CYS67 5.0 78.0 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of the MSL1-MSL2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the MSL1-MSL2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn502 b:94.1 occ:1.00 ND1 D:HIS64 2.1 87.1 1.0 CE1 D:HIS64 2.9 88.6 1.0 CG D:HIS64 3.1 83.0 1.0 SG D:CYS62 3.3 94.1 1.0 CB D:CYS62 3.4 91.8 1.0 CB D:HIS64 3.6 80.9 1.0 NE2 D:HIS64 4.1 85.4 1.0 CD2 D:HIS64 4.2 81.9 1.0 O D:CYS62 4.5 80.6 1.0 CA D:CYS62 4.6 86.9 1.0 C D:CYS62 4.6 81.5 1.0 N D:HIS64 4.7 75.9 1.0 CA D:HIS64 4.8 75.8 1.0

E.Hallacli, M.Lipp, P.Georgiev, C.Spielman, S.Cusack, A.Akhtar, J.Kadlec. MSL1-Mediated Dimerization of the Dosage Compensation Complex Is Essential For Male X-Chromosome Regulation in Drosophila. Mol.Cell V. 48 587 2012.
ISSN: ISSN 1097-2765
PubMed: 23084835
DOI: 10.1016/J.MOLCEL.2012.09.014