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Zinc in PDB 4ayk: Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures

Enzymatic activity of Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures

All present enzymatic activity of Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures:
3.4.24.7;

Other elements in 4ayk:

The structure of Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures also contains other interesting chemical elements:

Calcium (Ca) 30 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures (pdb code 4ayk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures, PDB code: 4ayk:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4ayk

Go back to Zinc Binding Sites List in 4ayk
Zinc binding site 1 out of 2 in the Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn170

b:0.0
occ:1.00
H50 A:CGS173 1.2 0.0 1.0
NE2 A:HIS122 2.0 0.0 1.0
NE2 A:HIS128 2.0 0.0 1.0
O48 A:CGS173 2.1 0.0 1.0
NE2 A:HIS118 2.1 0.0 1.0
O47 A:CGS173 2.1 0.0 1.0
C34 A:CGS173 2.8 0.0 1.0
N35 A:CGS173 2.8 0.0 1.0
CE1 A:HIS122 2.9 0.0 1.0
CE1 A:HIS118 2.9 0.0 1.0
CE1 A:HIS128 3.0 0.0 1.0
HE1 A:HIS122 3.0 0.0 1.0
HE1 A:HIS128 3.1 0.0 1.0
HE1 A:HIS118 3.1 0.0 1.0
CD2 A:HIS118 3.2 0.0 1.0
CD2 A:HIS128 3.2 0.0 1.0
CD2 A:HIS122 3.2 0.0 1.0
HD2 A:HIS118 3.5 0.0 1.0
HD2 A:HIS128 3.5 0.0 1.0
HD2 A:HIS122 3.5 0.0 1.0
H49 A:CGS173 3.8 0.0 1.0
HE3 A:MET136 3.9 0.0 1.0
ND1 A:HIS118 4.1 0.0 1.0
ND1 A:HIS122 4.1 0.0 1.0
ND1 A:HIS128 4.2 0.0 1.0
CG A:HIS118 4.2 0.0 1.0
CG A:HIS122 4.3 0.0 1.0
CG A:HIS128 4.3 0.0 1.0
CA A:CGS173 4.3 0.0 1.0
HA A:PRO138 4.3 0.0 1.0
HB A:CGS173 4.4 0.0 1.0
HC1 A:CGS173 4.5 0.0 1.0
CE1 A:CGS173 4.8 0.0 1.0
CD1 A:CGS173 4.8 0.0 1.0
HA A:CGS173 4.8 0.0 1.0
CE A:MET136 4.9 0.0 1.0
CB A:CGS173 4.9 0.0 1.0
HE1 A:CGS173 4.9 0.0 1.0
HD1 A:CGS173 4.9 0.0 1.0
O A:PRO138 4.9 0.0 1.0
HD1 A:HIS118 5.0 0.0 1.0
O A:TYR137 5.0 0.0 1.0
HD1 A:HIS122 5.0 0.0 1.0
HE1 A:MET136 5.0 0.0 1.0

Zinc binding site 2 out of 2 in 4ayk

Go back to Zinc Binding Sites List in 4ayk
Zinc binding site 2 out of 2 in the Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Catalytic Fragment of Human Fibroblast Collagenase Complexed with Cgs- 27023A, uc(Nmr), 30 Structures within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn171

b:0.0
occ:1.00
ND1 A:HIS96 2.0 0.0 1.0
NE2 A:HIS68 2.1 0.0 1.0
NE2 A:HIS83 2.2 0.0 1.0
HG21 A:VAL64 2.4 0.0 1.0
HB2 A:HIS96 2.6 0.0 1.0
CD2 A:HIS68 2.7 0.0 1.0
HD2 A:HIS68 2.7 0.0 1.0
HE1 A:HIS83 2.8 0.0 1.0
CE1 A:HIS83 2.8 0.0 1.0
HB3 A:HIS96 2.9 0.0 1.0
CG A:HIS96 2.9 0.0 1.0
CB A:HIS96 2.9 0.0 1.0
CE1 A:HIS96 3.1 0.0 1.0
CE1 A:HIS68 3.2 0.0 1.0
HE1 A:HIS96 3.4 0.0 1.0
HG12 A:VAL64 3.5 0.0 1.0
CD2 A:HIS83 3.5 0.0 1.0
HE2 A:PHE74 3.5 0.0 1.0
CG2 A:VAL64 3.5 0.0 1.0
HE1 A:HIS68 3.7 0.0 1.0
HG22 A:VAL64 3.8 0.0 1.0
CG A:HIS68 3.9 0.0 1.0
HD2 A:HIS83 3.9 0.0 1.0
HG23 A:VAL64 4.0 0.0 1.0
OD2 A:ASP70 4.0 0.0 1.0
ND1 A:HIS83 4.1 0.0 1.0
ND1 A:HIS68 4.1 0.0 1.0
CD2 A:HIS96 4.1 0.0 1.0
NE2 A:HIS96 4.2 0.0 1.0
CG1 A:VAL64 4.3 0.0 1.0
CB A:VAL64 4.4 0.0 1.0
CE2 A:PHE74 4.4 0.0 1.0
CG A:HIS83 4.4 0.0 1.0
CG A:ASP70 4.4 0.0 1.0
CA A:HIS96 4.5 0.0 1.0
HB A:VAL64 4.5 0.0 1.0
HZ A:PHE74 4.5 0.0 1.0
HB2 A:ASP70 4.6 0.0 1.0
HG11 A:VAL64 4.6 0.0 1.0
H A:HIS96 4.9 0.0 1.0
HD1 A:HIS83 4.9 0.0 1.0
HB3 A:ASP70 4.9 0.0 1.0
CB A:ASP70 4.9 0.0 1.0
CZ A:PHE74 4.9 0.0 1.0
OD1 A:ASP70 5.0 0.0 1.0

Reference:

F.J.Moy, P.K.Chanda, J.M.Chen, S.Cosmi, W.Edris, J.S.Skotnicki, J.Wilhelm, R.Powers. uc(Nmr) Solution Structure of the Catalytic Fragment of Human Fibroblast Collagenase Complexed with A Sulfonamide Derivative of A Hydroxamic Acid Compound. Biochemistry V. 38 7085 1999.
ISSN: ISSN 0006-2960
PubMed: 10353819
DOI: 10.1021/BI982576V
Page generated: Wed Aug 20 16:03:58 2025

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