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Zinc in PDB 4a49: Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex

Enzymatic activity of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex

All present enzymatic activity of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex:
2.3.2.23; 2.3.2.24; 2.3.2.27;

Protein crystallography data

The structure of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex, PDB code: 4a49 was solved by H.Dou, L.Buetow, A.Hock, G.J.Sibbet, K.H.Vousden, D.T.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.30 / 2.21
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 115.877, 115.877, 52.572, 90.00, 90.00, 120.00
R / Rfree (%) 16.8 / 20.6

Other elements in 4a49:

The structure of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex also contains other interesting chemical elements:

Potassium (K) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex (pdb code 4a49). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex, PDB code: 4a49:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4a49

Go back to Zinc Binding Sites List in 4a49
Zinc binding site 1 out of 2 in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1436

b:42.4
occ:1.00
SG A:CYS404 2.3 41.7 1.0
SG A:CYS384 2.4 39.2 1.0
SG A:CYS381 2.4 37.8 1.0
SG A:CYS401 2.5 43.8 1.0
CB A:CYS384 3.2 32.8 1.0
CB A:CYS381 3.2 41.7 1.0
CB A:CYS404 3.3 39.5 1.0
CB A:CYS401 3.4 39.3 1.0
N A:CYS384 3.5 30.3 1.0
CA A:CYS384 3.9 31.8 1.0
N A:CYS401 3.9 43.3 1.0
CA A:CYS401 4.1 45.8 1.0
O A:HOH2033 4.3 48.0 1.0
N A:CYS404 4.4 36.9 1.0
CA A:CYS404 4.4 35.7 1.0
CB A:ILE383 4.5 41.2 1.0
OD1 A:ASN387 4.6 64.8 1.0
C A:ILE383 4.6 39.1 1.0
O A:CYS401 4.6 47.6 1.0
CA A:CYS381 4.6 34.9 1.0
CB A:ASN387 4.6 44.7 1.0
C A:CYS401 4.7 51.6 1.0
O A:CYS381 4.8 34.1 1.0
C A:CYS381 4.9 34.8 1.0
CA A:ILE383 4.9 34.6 1.0
O A:ASN387 4.9 44.5 1.0
C A:CYS384 4.9 34.5 1.0
N A:ILE383 4.9 37.9 1.0
N A:ASN387 5.0 48.0 1.0

Zinc binding site 2 out of 2 in 4a49

Go back to Zinc Binding Sites List in 4a49
Zinc binding site 2 out of 2 in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1437

b:50.4
occ:1.00
ND1 A:HIS398 2.0 42.1 1.0
SG A:CYS416 2.3 50.2 1.0
SG A:CYS419 2.4 59.7 1.0
SG A:CYS396 2.5 54.7 1.0
CE1 A:HIS398 2.7 57.5 1.0
CG A:HIS398 3.1 45.5 1.0
CB A:CYS416 3.1 47.6 1.0
CB A:CYS396 3.3 54.4 1.0
N A:CYS419 3.6 51.3 1.0
CB A:CYS419 3.6 56.3 1.0
CB A:HIS398 3.6 44.2 1.0
NE2 A:HIS398 3.8 53.6 1.0
CD2 A:HIS398 4.0 44.0 1.0
CB A:PHE418 4.0 59.8 1.0
CA A:CYS419 4.2 54.5 1.0
CA A:CYS416 4.6 49.8 1.0
C A:PHE418 4.6 53.2 1.0
N A:HIS398 4.6 47.6 1.0
CA A:PHE418 4.6 52.6 1.0
CA A:CYS396 4.7 60.4 1.0
N A:PHE418 4.7 56.4 1.0
CA A:HIS398 4.8 47.1 1.0
CG2 A:ILE393 4.8 57.8 1.0
C A:CYS419 4.9 58.6 1.0
C A:CYS416 5.0 52.4 1.0
N A:ARG420 5.0 63.4 1.0

Reference:

H.Dou, L.Buetow, A.Hock, G.J.Sibbet, K.H.Vousden, D.T.Huang. Structural Basis For Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat. Struct. Mol. Biol. V. 19 184 2012.
ISSN: ESSN 1545-9985
PubMed: 22266821
DOI: 10.1038/NSMB.2231
Page generated: Sat Oct 26 19:03:03 2024

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