Zinc in PDB 3v7m: Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+

The structure of Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+, PDB code: 3v7m was solved by R.Menez, E.A.Stura, D.Bourel, S.Siberil, S.Jorieux, C.De Romeuf, F.Ducancel, W.H.Fridman, J.L.Teillaud, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.24 / 2.02
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	50.220, 147.750, 75.540, 90.00, 90.00, 90.00
R / Rfree (%)	23.4 / 28.6

The binding sites of Zinc atom in the Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+ (pdb code 3v7m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+, PDB code: 3v7m:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn509 b:38.8 occ:1.00 NE2 A:HIS310 2.0 32.6 1.0 N3 A:IMD514 2.1 30.1 0.5 NE2 A:HIS435 2.2 34.0 1.0 N1 A:IMD513 2.3 31.4 0.5 C2 A:IMD513 2.4 29.5 0.5 C4 A:IMD514 2.9 36.4 0.5 CD2 A:HIS310 3.0 29.8 1.0 CE1 A:HIS310 3.0 26.9 1.0 O A:HOH676 3.1 58.0 1.0 CE1 A:HIS435 3.1 34.8 1.0 CD2 A:HIS435 3.2 33.6 1.0 C2 A:IMD514 3.3 36.6 0.5 C5 A:IMD513 3.6 33.5 0.5 N3 A:IMD513 3.7 30.7 0.5 CD1 A:LEU314 3.9 27.3 1.0 ND1 A:HIS310 4.1 31.1 1.0 CG A:HIS310 4.2 31.4 1.0 C5 A:IMD514 4.2 39.7 0.5 ND1 A:HIS435 4.3 31.3 1.0 CG A:HIS435 4.3 31.8 1.0 N1 A:IMD514 4.3 37.9 0.5 C4 A:IMD513 4.3 34.4 0.5 O A:HOH684 4.7 59.3 1.0 NE2 A:GLN311 4.9 20.0 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn510 b:63.5 occ:1.00 N3 A:IMD512 1.7 41.6 1.0 C4 A:IMD512 2.2 48.5 1.0 ND1 A:HIS285 2.3 48.2 1.0 C2 A:IMD512 3.0 46.4 1.0 CE1 A:HIS285 3.0 46.8 1.0 CG A:HIS285 3.4 46.7 1.0 C5 A:IMD512 3.6 50.2 1.0 OE2 A:GLU283 3.7 55.8 1.0 O A:HOH636 3.7 51.6 1.0 N1 A:IMD512 3.9 50.3 1.0 CB A:HIS285 3.9 48.4 1.0 CA A:HIS285 4.2 49.0 1.0 NE2 A:HIS285 4.2 44.5 1.0 CD2 A:HIS285 4.4 43.0 1.0 O A:VAL284 4.7 45.3 1.0 O A:HIS285 4.8 50.6 1.0 CD A:GLU283 4.9 54.6 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Monoclonal Human Anti-Rhesus D Fc IGG1 T125(YB2/0) in the Presence of ZN2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn511 b:48.3 occ:0.30 ND1 A:HIS433 1.7 35.5 0.5 CE1 A:HIS433 2.4 36.5 0.5 O A:HOH733 2.5 54.7 1.0 O A:HOH719 2.9 54.9 1.0 CG A:HIS433 3.0 34.3 0.5 O A:HOH675 3.0 63.4 1.0 O A:HOH660 3.5 55.5 1.0 NE2 A:HIS433 3.6 32.4 0.5 CB A:HIS433 3.7 32.4 0.5 O A:HOH720 3.7 51.3 1.0 CD2 A:HIS433 3.9 33.1 0.5 O A:HOH606 3.9 62.6 1.0 CA A:HIS433 4.1 33.3 1.0 O A:HOH631 4.9 60.6 1.0

S.Siberil, R.Menez, S.Jorieux, C.De Romeuf, D.Bourel, W.H.Fridman, F.Ducancel, E.A.Stura, J.L.Teillaud. Effect of Zinc on Human IGG1 and Its Fc Gamma R Interactions. Immunol.Lett. V. 143 60 2012.
ISSN: ISSN 0165-2478
PubMed: 22553781