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Atomistry » Zinc » PDB 3u6q-3uec » 3udp » |
Zinc in PDB 3udp: Crystal Structure of Bace with Compound 12Enzymatic activity of Crystal Structure of Bace with Compound 12
All present enzymatic activity of Crystal Structure of Bace with Compound 12:
3.4.23.46; Protein crystallography data
The structure of Crystal Structure of Bace with Compound 12, PDB code: 3udp
was solved by
I.V.Efremov,
F.F.Vajdos,
K.Borzilleri,
S.Capetta,
P.Dorff,
J.Dutra,
M.Mansour,
C.Oborski,
T.O'connell,
T.J.O'sullivan,
J.Pandit,
H.Wang,
J.Withka,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3udp:
The structure of Crystal Structure of Bace with Compound 12 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Bace with Compound 12
(pdb code 3udp). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Bace with Compound 12, PDB code: 3udp: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 3udpGo back to![]() ![]()
Zinc binding site 1 out
of 2 in the Crystal Structure of Bace with Compound 12
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 3udpGo back to![]() ![]()
Zinc binding site 2 out
of 2 in the Crystal Structure of Bace with Compound 12
![]() Mono view ![]() Stereo pair view
Reference:
I.V.Efremov,
F.F.Vajdos,
K.A.Borzilleri,
S.Capetta,
H.Chen,
P.H.Dorff,
J.K.Dutra,
S.W.Goldstein,
M.Mansour,
A.Mccoll,
S.Noell,
C.E.Oborski,
T.N.O'connell,
T.J.O'sullivan,
J.Pandit,
H.Wang,
B.Wei,
J.M.Withka.
Discovery and Optimization of A Novel Spiropyrrolidine Inhibitor of {Beta}-Secretase (BACE1) Through Fragment-Based Drug Design. J.Med.Chem. V. 55 9069 2012.
Page generated: Sat Oct 26 17:11:43 2024
ISSN: ISSN 0022-2623 PubMed: 22468999 DOI: 10.1021/JM201715D |
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