Zinc in PDB 3sug: Crystal Structure of NS3/4A Protease Variant A156T in Complex with Mk- 5172

The structure of Crystal Structure of NS3/4A Protease Variant A156T in Complex with Mk- 5172, PDB code: 3sug was solved by C.A.Schiffer, K.P.Romano, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.68 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	53.883, 58.248, 62.026, 90.00, 90.00, 90.00
R / Rfree (%)	19.2 / 23.4

The binding sites of Zinc atom in the Crystal Structure of NS3/4A Protease Variant A156T in Complex with Mk- 5172 (pdb code 3sug). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of NS3/4A Protease Variant A156T in Complex with Mk- 5172, PDB code: 3sug:

Zinc binding site 1 out of 1 in the Crystal Structure of NS3/4A Protease Variant A156T in Complex with Mk- 5172


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of NS3/4A Protease Variant A156T in Complex with Mk- 5172 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1203 b:51.4 occ:1.00 SG A:CYS1145 2.1 44.2 1.0 SG A:CYS1097 2.3 52.1 1.0 ND1 A:HIS1149 2.3 57.8 1.0 SG A:CYS1099 2.5 58.9 1.0 CG A:HIS1149 3.3 55.7 1.0 CB A:CYS1145 3.3 46.8 1.0 CB A:CYS1099 3.3 58.4 1.0 CE1 A:HIS1149 3.3 60.4 1.0 CB A:CYS1097 3.5 51.2 1.0 CB A:HIS1149 3.5 52.8 1.0 N A:CYS1099 3.8 59.4 1.0 CA A:CYS1097 3.8 52.7 1.0 N A:THR1098 4.0 57.6 1.0 CA A:CYS1099 4.2 60.7 1.0 C A:CYS1097 4.4 54.8 1.0 NE2 A:HIS1149 4.4 60.2 1.0 CD2 A:HIS1149 4.4 58.4 1.0 CB A:ALA1147 4.5 58.6 1.0 CA A:HIS1149 4.7 50.8 1.0 CA A:CYS1145 4.8 48.0 1.0 N A:HIS1149 4.8 53.2 1.0 C A:THR1098 4.9 61.2 1.0

K.P.Romano, A.Ali, C.Aydin, D.Soumana, A.Ozen, L.M.Deveau, C.Silver, H.Cao, A.Newton, C.J.Petropoulos, W.Huang, C.A.Schiffer. The Molecular Basis of Drug Resistance Against Hepatitis C Virus NS3/4A Protease Inhibitors. Plos Pathog. V. 8 02832 2012.
ISSN: ISSN 1553-7366
PubMed: 22910833
DOI: 10.1371/JOURNAL.PPAT.1002832