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Atomistry » Zinc » PDB 3sje-3sue » 3sn7 » |
Zinc in PDB 3sn7: Highly Potent, Selective, and Orally Active Phosphodiestarase 10A InhibitorsEnzymatic activity of Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
All present enzymatic activity of Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors, PDB code: 3sn7
was solved by
K.D.Parris,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3sn7:
The structure of Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
(pdb code 3sn7). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors, PDB code: 3sn7: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 3sn7Go back to![]() ![]()
Zinc binding site 1 out
of 2 in the Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 3sn7Go back to![]() ![]()
Zinc binding site 2 out
of 2 in the Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
![]() Mono view ![]() Stereo pair view
Reference:
M.S.Malamas,
Y.Ni,
J.Erdei,
H.Stange,
R.Schindler,
H.J.Lankau,
C.Grunwald,
K.Y.Fan,
K.Parris,
B.Langen,
U.Egerland,
T.Hage,
K.L.Marquis,
S.Grauer,
J.Brennan,
R.Navarra,
R.Graf,
B.L.Harrison,
A.Robichaud,
T.Kronbach,
M.N.Pangalos,
N.Hoefgen,
N.J.Brandon.
Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors. J.Med.Chem. V. 54 7621 2011.
Page generated: Sat Oct 26 15:53:50 2024
ISSN: ISSN 0022-2623 PubMed: 21988093 DOI: 10.1021/JM2009138 |
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