Atomistry » Zinc » PDB 3sck-3sjd » 3sfx
Atomistry »
  Zinc »
    PDB 3sck-3sjd »
      3sfx »

Zinc in PDB 3sfx: Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib

Protein crystallography data

The structure of Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib, PDB code: 3sfx was solved by M.A.Hast, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.47 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 142.176, 142.176, 130.096, 90.00, 90.00, 90.00
R / Rfree (%) 18 / 19.9

Other elements in 3sfx:

The structure of Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib (pdb code 3sfx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib, PDB code: 3sfx:

Zinc binding site 1 out of 1 in 3sfx

Go back to Zinc Binding Sites List in 3sfx
Zinc binding site 1 out of 1 in the Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryptococcus Neoformans Protein Farnesyltransferase in Complex with Fpt-II and Tipifarnib within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn521

b:27.7
occ:1.00
OD2 B:ASP323 2.1 27.1 1.0
NE2 B:HIS410 2.1 24.2 1.0
N2 B:JAN526 2.2 36.5 0.8
SG B:CYS325 2.3 24.0 1.0
OD1 B:ASP323 2.6 21.6 1.0
CG B:ASP323 2.6 22.9 1.0
CD2 B:HIS410 3.0 23.4 1.0
C2 B:JAN526 3.0 38.3 0.8
CE1 B:HIS410 3.2 25.1 1.0
C3 B:JAN526 3.2 36.5 0.8
CB B:CYS325 3.3 23.0 1.0
CE2 B:TYR409 4.0 25.0 1.0
CB B:ASP323 4.1 22.8 1.0
N B:CYS325 4.1 22.8 1.0
CG B:HIS410 4.2 22.7 1.0
ND1 B:HIS410 4.2 22.7 1.0
N1 B:JAN526 4.2 38.1 0.8
O B:HOH2092 4.2 19.3 1.0
CA B:CYS325 4.3 22.9 1.0
C4 B:JAN526 4.3 36.7 0.8
CB B:ASP400 4.3 26.2 1.0
O B:HOH2474 4.3 37.9 1.0
CG B:ASP400 4.5 28.2 1.0
OH B:TYR409 4.7 27.1 1.0
OD2 B:ASP400 4.7 30.4 1.0
CA B:ASP400 4.7 25.2 1.0
O B:HOH2588 4.8 46.6 1.0
CE2 B:TYR326 4.8 22.8 1.0
CZ B:TYR409 4.9 26.7 1.0
OD1 B:ASP400 4.9 29.8 1.0
CD2 B:TYR409 4.9 23.9 1.0
CZ B:TYR326 5.0 22.2 1.0

Reference:

M.A.Hast, C.B.Nichols, S.M.Armstrong, S.M.Kelly, H.W.Hellinga, J.A.Alspaugh, L.S.Beese. Structures of Cryptococcus Neoformans Protein Farnesyltransferase Reveal Strategies For Developing Inhibitors That Target Fungal Pathogens. J.Biol.Chem. V. 286 35149 2011.
ISSN: ISSN 0021-9258
PubMed: 21816822
DOI: 10.1074/JBC.M111.250506
Page generated: Sat Oct 26 15:44:38 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy