Atomistry » Zinc » PDB 3s2s-3scj » 3s3n
Atomistry »
  Zinc »
    PDB 3s2s-3scj »
      3s3n »

Zinc in PDB 3s3n: Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572)

Protein crystallography data

The structure of Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572), PDB code: 3s3n was solved by S.Hare, P.Cherepanov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.16 / 2.49
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 160.050, 160.050, 123.610, 90.00, 90.00, 90.00
R / Rfree (%) 20.9 / 23.2

Other elements in 3s3n:

The structure of Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572) also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Magnesium (Mg) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572) (pdb code 3s3n). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572), PDB code: 3s3n:

Zinc binding site 1 out of 1 in 3s3n

Go back to Zinc Binding Sites List in 3s3n
Zinc binding site 1 out of 1 in the Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Prototype Foamy Virus (Pfv) S217H Mutant Intasome in Complex with Magnesium and Dolutegravir (S/GSK1349572) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn393

b:45.6
occ:1.00
NE2 A:HIS62 2.0 42.8 1.0
ND1 A:HIS66 2.1 43.2 1.0
SG A:CYS96 2.2 47.8 1.0
SG A:CYS99 2.3 47.2 1.0
CE1 A:HIS62 3.0 44.1 1.0
CD2 A:HIS62 3.0 42.7 1.0
CG A:HIS66 3.1 43.5 1.0
CE1 A:HIS66 3.1 44.8 1.0
CB A:HIS66 3.3 42.7 1.0
CB A:CYS96 3.3 50.8 1.0
CB A:CYS99 3.4 47.8 1.0
CA A:HIS66 3.9 42.9 1.0
N A:CYS99 3.9 48.0 1.0
ND1 A:HIS62 4.1 43.9 1.0
CA A:CYS99 4.1 47.7 1.0
CG A:HIS62 4.2 45.0 1.0
NE2 A:HIS66 4.2 44.6 1.0
CD2 A:HIS66 4.2 43.6 1.0
O A:HOH443 4.3 47.0 1.0
C A:HIS66 4.5 42.6 1.0
O A:HIS66 4.7 41.7 1.0
CB A:GLN98 4.7 50.7 1.0
CA A:CYS96 4.7 51.5 1.0
OD1 A:ASN63 4.8 52.9 1.0
C A:GLN98 4.8 49.2 1.0
O A:CYS96 5.0 50.8 1.0

Reference:

S.Hare, S.J.Smith, M.Metifiot, A.Jaxa-Chamiec, Y.Pommier, S.H.Hughes, P.Cherepanov. Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572). Mol.Pharmacol. V. 80 565 2011.
ISSN: ISSN 0026-895X
PubMed: 21719464
DOI: 10.1124/MOL.111.073189
Page generated: Sat Oct 26 15:33:01 2024

Last articles

Na in 2QB4
Na in 2QD6
Na in 2QCI
Na in 2QA0
Na in 2Q95
Na in 2Q96
Na in 2Q94
Na in 2Q93
Na in 2Q8X
Na in 2Q72
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy