Zinc in PDB 3q7b: Exonuclease Domain of Lassa Virus Nucleoprotein

The structure of Exonuclease Domain of Lassa Virus Nucleoprotein, PDB code: 3q7b was solved by K.M.Hastie, C.R.Kimberlin, M.A.Zandonatti, I.J.Macrae, E.O.Saphire, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.00 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.998, 68.233, 79.006, 90.00, 90.00, 90.00
R / Rfree (%)	18.9 / 25.4

The binding sites of Zinc atom in the Exonuclease Domain of Lassa Virus Nucleoprotein (pdb code 3q7b). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Exonuclease Domain of Lassa Virus Nucleoprotein, PDB code: 3q7b:

Zinc binding site 1 out of 1 in the Exonuclease Domain of Lassa Virus Nucleoprotein


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Exonuclease Domain of Lassa Virus Nucleoprotein within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:14.5 occ:1.00 OE2 A:GLU399 2.1 11.3 1.0 NE2 A:HIS509 2.1 15.3 1.0 SG A:CYS506 2.3 11.3 1.0 SG A:CYS529 2.4 17.4 1.0 CD2 A:HIS509 2.9 13.5 1.0 CD A:GLU399 3.0 16.9 1.0 OE1 A:GLU399 3.2 14.4 1.0 CE1 A:HIS509 3.2 9.1 1.0 CB A:CYS529 3.3 10.1 1.0 CB A:CYS506 3.4 8.4 1.0 NE2 A:HIS412 3.7 13.2 1.0 CA A:CYS529 3.9 9.9 1.0 CE1 A:HIS412 4.1 13.0 1.0 CG A:HIS509 4.2 17.2 1.0 CZ A:PHE414 4.2 9.8 1.0 ND1 A:HIS509 4.3 12.4 1.0 CG A:GLU399 4.4 8.3 1.0 N A:ALA530 4.4 10.2 1.0 C A:CYS529 4.5 9.7 1.0 CE1 A:PHE414 4.5 11.6 1.0 CA A:CYS506 4.8 13.5 1.0 N A:LEU531 4.9 10.1 1.0 CD2 A:HIS412 4.9 10.7 1.0 CB A:MET508 5.0 12.7 1.0

K.M.Hastie, C.R.Kimberlin, M.A.Zandonatti, I.J.Macrae, E.O.Saphire. Structure of the Lassa Virus Nucleoprotein Reveals A Dsrna-Specific 3' to 5' Exonuclease Activity Essential For Immune Suppression. Proc.Natl.Acad.Sci.Usa V. 108 2396 2011.
ISSN: ISSN 0027-8424
PubMed: 21262835
DOI: 10.1073/PNAS.1016404108