Atomistry » Zinc » PDB 3p4v-3phd » 3p55
Atomistry »
  Zinc »
    PDB 3p4v-3phd »
      3p55 »

Zinc in PDB 3p55: Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide

Enzymatic activity of Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide

All present enzymatic activity of Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide:
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide, PDB code: 3p55 was solved by A.J.Salmon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.400, 41.600, 72.230, 90.00, 104.64, 90.00
R / Rfree (%) 18.7 / 22.3

Other elements in 3p55:

The structure of Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide also contains other interesting chemical elements:

Iron (Fe) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide (pdb code 3p55). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide, PDB code: 3p55:

Zinc binding site 1 out of 1 in 3p55

Go back to Zinc Binding Sites List in 3p55
Zinc binding site 1 out of 1 in the Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase II in Complex with P-(4-Ferrocenyl-1H-1,2,3- Triazol-1-Yl)Benzenesulfonamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn261

b:11.1
occ:1.00
 NAK A:670300 2.1 10.1 1.0
ND1 A:HIS119 2.1 9.9 1.0
NE2 A:HIS96 2.1 8.1 1.0
NE2 A:HIS94 2.1 9.2 1.0
CD2 A:HIS96 2.9 9.3 1.0
CD2 A:HIS94 3.0 9.8 1.0
CE1 A:HIS119 3.0 11.0 1.0
OAE A:670300 3.1 11.2 1.0
CG A:HIS119 3.2 7.4 1.0
SAJ A:670300 3.2 13.8 1.0
CE1 A:HIS94 3.2 10.0 1.0
CE1 A:HIS96 3.2 10.5 1.0
CB A:HIS119 3.6 6.6 1.0
OG1 A:THR198 3.8 12.8 1.0
OE1 A:GLU106 3.9 10.7 1.0
NE2 A:HIS119 4.1 8.8 1.0
CG A:HIS96 4.1 7.3 1.0
CG A:HIS94 4.2 8.8 1.0
CD2 A:HIS119 4.2 6.0 1.0
ND1 A:HIS96 4.2 9.0 1.0
ND1 A:HIS94 4.2 7.4 1.0
CAI A:670300 4.3 13.7 1.0
OAO A:670300 4.3 8.9 1.0
C1 A:GOL301 4.4 25.7 1.0
CAD A:670300 4.8 14.2 1.0
CD A:GLU106 4.9 9.5 1.0
CH2 A:TRP208 5.0 6.8 1.0

Reference:

A.J.Salmon, M.L.Williams, A.Hofmann, S.A.Poulsen. Protein Crystal Structures with Ferrocene and Ruthenocene-Based Enzyme Inhibitors. Chem.Commun.(Camb.) V. 48 2328 2012.
ISSN: ISSN 1359-7345
PubMed: 22258283
DOI: 10.1039/C2CC15625C
Page generated: Sat Oct 26 11:19:30 2024

Last articles

Yb in 3FUJ
Yb in 3FUI
Yb in 3FUH
Yb in 3FUF
Yb in 3FUE
Yb in 3FU6
Yb in 3FUD
Yb in 3FU0
Yb in 3FU3
Yb in 3FTZ
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy