Atomistry » Zinc » PDB 3oxk-3p44 » 3p0z
Atomistry »
  Zinc »
    PDB 3oxk-3p44 »
      3p0z »

Zinc in PDB 3p0z: Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol

Enzymatic activity of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol

All present enzymatic activity of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol:
4.6.1.12;

Protein crystallography data

The structure of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol, PDB code: 3p0z was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.83 / 1.95
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 117.550, 67.630, 59.770, 90.00, 95.99, 90.00
R / Rfree (%) 15.2 / 19.1

Other elements in 3p0z:

The structure of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol also contains other interesting chemical elements:

Potassium (K) 1 atom
Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol (pdb code 3p0z). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol, PDB code: 3p0z:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 3p0z

Go back to Zinc Binding Sites List in 3p0z
Zinc binding site 1 out of 3 in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn164

b:18.7
occ:1.00
NFE A:MSR170 1.9 29.8 1.0
OD2 A:ASP10 2.0 14.9 1.0
ND1 A:HIS44 2.0 15.2 1.0
NE2 A:HIS12 2.1 15.6 1.0
CG A:ASP10 2.8 16.5 1.0
C2 A:MSR170 2.9 32.1 1.0
C5 A:MSR170 2.9 33.0 1.0
CE1 A:HIS44 3.0 17.5 1.0
OD1 A:ASP10 3.0 16.4 1.0
CD2 A:HIS12 3.0 15.4 1.0
CG A:HIS44 3.0 15.8 1.0
CE1 A:HIS12 3.1 20.9 1.0
CB A:HIS44 3.4 13.3 1.0
N3 A:MSR170 3.9 36.4 1.0
C4 A:MSR170 4.0 32.9 1.0
NE2 A:HIS44 4.1 15.1 1.0
CD2 A:HIS44 4.2 16.2 1.0
CG A:HIS12 4.2 15.8 1.0
ND1 A:HIS12 4.2 19.9 1.0
CB A:ASP10 4.2 12.8 1.0
NZ B:LYS134 4.3 30.7 1.0
O A:HOH176 4.4 6.2 1.0
CA A:VAL41 4.5 12.3 1.0
O A:ASP40 4.7 12.4 1.0
CA A:HIS44 4.9 12.8 1.0
C A:ASP40 4.9 13.5 1.0
N A:VAL41 5.0 13.3 1.0
C A:ALA39 5.0 16.6 1.0

Zinc binding site 2 out of 3 in 3p0z

Go back to Zinc Binding Sites List in 3p0z
Zinc binding site 2 out of 3 in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn163

b:34.0
occ:1.00
NE2 B:HIS12 1.9 24.8 1.0
ND1 B:HIS44 1.9 26.0 1.0
OD2 B:ASP10 2.1 23.7 1.0
O B:HOH176 2.5 20.3 1.0
CE1 B:HIS12 2.7 36.3 1.0
CG B:ASP10 2.8 23.8 1.0
CE1 B:HIS44 2.8 33.8 1.0
OD1 B:ASP10 2.9 20.8 1.0
CD2 B:HIS12 3.0 29.9 1.0
CG B:HIS44 3.0 26.5 1.0
CB B:HIS44 3.5 25.0 1.0
ND1 B:HIS12 3.9 32.9 1.0
NE2 B:HIS44 4.0 31.2 1.0
CG B:HIS12 4.0 29.2 1.0
CD2 B:HIS44 4.1 32.2 1.0
NZ C:LYS134 4.2 38.1 1.0
CB B:ASP10 4.2 20.7 1.0
CA B:VAL41 4.6 24.3 1.0
O B:ASP40 4.7 26.1 1.0
O B:HOH200 4.8 27.6 1.0
O B:VAL11 4.9 27.6 1.0
CA B:HIS44 5.0 25.0 1.0

Zinc binding site 3 out of 3 in 3p0z

Go back to Zinc Binding Sites List in 3p0z
Zinc binding site 3 out of 3 in the Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase From Burkholderia Pseudomallei with Cytidine and FOL955, 4- (1H-Imidazol)-1-Yl)Phenol within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn164

b:25.7
occ:1.00
NE2 C:HIS12 1.9 29.5 1.0
OD2 C:ASP10 2.0 21.2 1.0
ND1 C:HIS44 2.1 16.9 1.0
O A:HOH177 2.1 14.9 1.0
CG C:ASP10 2.8 18.4 1.0
CD2 C:HIS12 2.9 25.9 1.0
CE1 C:HIS12 2.9 29.4 1.0
CE1 C:HIS44 3.0 20.9 1.0
OD1 C:ASP10 3.0 19.4 1.0
CG C:HIS44 3.1 18.4 1.0
CB C:HIS44 3.4 18.2 1.0
ND1 C:HIS12 4.0 30.8 1.0
CG C:HIS12 4.1 23.8 1.0
NE2 C:HIS44 4.1 23.5 1.0
CD2 C:HIS44 4.2 21.6 1.0
CB C:ASP10 4.2 16.9 1.0
NZ A:LYS134 4.3 35.7 1.0
CA C:VAL41 4.6 20.0 1.0
O C:ASP40 4.8 20.1 1.0
CA C:HIS44 4.9 17.6 1.0
N C:VAL41 5.0 21.2 1.0

Reference:

D.W.Begley, R.C.Hartley, D.R.Davies, T.E.Edwards, J.T.Leonard, J.Abendroth, C.A.Burris, J.Bhandari, P.J.Myler, B.L.Staker, L.J.Stewart. Leveraging Structure Determination with Fragment Screening For Infectious Disease Drug Targets: Mecp Synthase From Burkholderia Pseudomallei. J Struct Funct Genomics V. 12 63 2011.
PubMed: 21359640
DOI: 10.1007/S10969-011-9102-6
Page generated: Sat Oct 26 11:14:36 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy