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Atomistry » Zinc » PDB 3oxk-3p44 » 3oys » |
Zinc in PDB 3oys: Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-OneEnzymatic activity of Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-One
All present enzymatic activity of Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-One:
4.2.1.1; Protein crystallography data
The structure of Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-One, PDB code: 3oys
was solved by
M.Aggarwal,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-One
(pdb code 3oys). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-One, PDB code: 3oys: Zinc binding site 1 out of 1 in 3oysGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Human Carbonic Anhydrase II Complexed with 2-{[4-Amino-3-(3- Hydroxyprop-1-Yn-1-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl]Methyl}-5- Methyl-3-(2-Methylphenyl)Quinazolin-4(3H)-One
![]() Mono view ![]() Stereo pair view
Reference:
N.Hen,
M.Bialer,
B.Yagen,
A.Maresca,
M.Aggarwal,
A.H.Robbins,
R.Mckenna,
A.Scozzafava,
C.T.Supuran.
Anticonvulsant 4-Aminobenzenesulfonamide Derivatives with Branched-Alkylamide Moieties: X-Ray Crystallography and Inhibition Studies of Human Carbonic Anhydrase Isoforms I, II, VII, and Xiv. J.Med.Chem. V. 54 3977 2011.
Page generated: Sat Oct 26 11:13:40 2024
ISSN: ISSN 0022-2623 PubMed: 21506569 DOI: 10.1021/JM200209N |
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