Zinc in PDB 3n56: Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp)

All present enzymatic activity of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp):
3.4.24.56;

The structure of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp), PDB code: 3n56 was solved by T.Funke, Q.Guo, W.-J.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 3.10
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	264.036, 264.036, 90.645, 90.00, 90.00, 120.00
R / Rfree (%)	20.2 / 24.3

The binding sites of Zinc atom in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp) (pdb code 3n56). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp), PDB code: 3n56:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2001 b:72.8 occ:1.00 OE1 A:GLU189 1.9 59.0 1.0 NE2 A:HIS112 2.0 54.4 1.0 NE2 A:HIS108 2.1 51.1 1.0 CD A:GLU189 2.7 57.8 1.0 OE2 A:GLU189 2.8 59.0 1.0 CE1 A:HIS112 2.9 54.2 1.0 CE1 A:HIS108 3.0 51.0 1.0 CD2 A:HIS112 3.0 54.3 1.0 CD2 A:HIS108 3.2 51.1 1.0 ND1 A:HIS112 4.0 53.7 1.0 CG A:GLU189 4.1 55.2 1.0 CG A:HIS112 4.1 53.8 1.0 ND1 A:HIS108 4.2 50.9 1.0 CG A:HIS108 4.3 50.5 1.0 CE1 A:TYR831 4.5 50.3 1.0 CB A:GLU189 4.6 53.4 1.0 OH A:TYR831 4.8 52.0 1.0 NE2 A:GLN111 5.0 52.1 1.0 CZ A:TYR831 5.0 51.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2002 b:60.5 occ:1.00 OE1 B:GLU189 2.0 48.7 1.0 NE2 B:HIS112 2.0 44.9 1.0 NE2 B:HIS108 2.1 42.5 1.0 CD B:GLU189 2.7 48.3 1.0 OE2 B:GLU189 2.7 48.8 1.0 CE1 B:HIS108 3.0 42.5 1.0 CE1 B:HIS112 3.0 44.8 1.0 CD2 B:HIS112 3.1 44.9 1.0 CD2 B:HIS108 3.1 43.0 1.0 ND1 B:HIS108 4.1 42.7 1.0 ND1 B:HIS112 4.1 44.9 1.0 CG B:GLU189 4.2 47.9 1.0 CG B:HIS112 4.2 45.0 1.0 CG B:HIS108 4.2 43.4 1.0 CE1 B:TYR831 4.5 44.5 1.0 OH B:TYR831 4.6 45.5 1.0 OE1 B:GLN111 4.6 45.6 1.0 CB B:GLU189 4.7 47.5 1.0 NE2 B:GLN111 4.8 45.6 1.0 CZ B:TYR831 4.9 44.7 1.0

L.A.Ralat, T.Funke, M.Ren, Q.Guo, D.M.Dickey, L.R.Potter, W.-J.Tang. Crystal Structure of Human Insulin-Degrading Enzyme (Ide) in Complex with Human B-Type Natriuretic Peptide (Bnp) To Be Published.