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Zinc in PDB 3n2v: Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
Enzymatic activity of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
All present enzymatic activity of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide:
3.4.24.65;
3.4.24.65;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide, PDB code: 3n2v
was solved by
V.Calderone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 14.44 / 1.55 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.614, 60.277, 54.186, 90.00, 115.20, 90.00 |
| R / Rfree (%) | 13.2 / 18 |
Other elements in 3n2v:
The structure of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide also contains other interesting chemical elements:
| Calcium | (Ca) | 3 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
(pdb code 3n2v). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide, PDB code: 3n2v:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide, PDB code: 3n2v:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 3n2v
Go back to
Zinc Binding Sites List in 3n2v
Zinc binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide within 5.0Å range:
|
Zinc binding site 2 out of 2 in 3n2v
Go back to
Zinc Binding Sites List in 3n2v
Zinc binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of the Catalytic Domain of Human MMP12 Complexed with the Inhibitor N-Hydroxy-2-(N-Hydroxyethyl)Biphenyl-4- Ylsulfonamido)Acetamide within 5.0Å range:
|
Reference:
E.Attolino,
V.Calderone,
E.Dragoni,
M.Fragai,
B.Richichi,
C.Luchinat,
C.Nativi.
Structure-Based Approach to Nanomolar, Water Soluble Matrix Metalloproteinases Inhibitors (Mmpis). Eur.J.Med.Chem. V. 45 5919 2010.
ISSN: ISSN 0223-5234
PubMed: 20965620
DOI: 10.1016/J.EJMECH.2010.09.057
Page generated: Sat Oct 26 09:56:22 2024
ISSN: ISSN 0223-5234
PubMed: 20965620
DOI: 10.1016/J.EJMECH.2010.09.057
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