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Zinc in PDB 3lx3: Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin

Enzymatic activity of Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin

All present enzymatic activity of Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin:
4.2.3.12;

Protein crystallography data

The structure of Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin, PDB code: 3lx3 was solved by E.T.Larson, E.A.Merritt, Medical Structural Genomics Of Pathogenicprotozoa (Msgpp), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.12 / 1.55
Space group H 3 2
Cell size a, b, c (Å), α, β, γ (°) 131.358, 131.358, 73.577, 90.00, 90.00, 120.00
R / Rfree (%) 14.9 / 16.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin (pdb code 3lx3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin, PDB code: 3lx3:

Zinc binding site 1 out of 1 in 3lx3

Go back to Zinc Binding Sites List in 3lx3
Zinc binding site 1 out of 1 in the Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Plasmodium Vivax 6-Pyruvoyltetrahydropterin Synthase (Ptps) in Complex with Xanthopterin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn201

b:20.9
occ:1.00
 O A:HOH256 2.1 24.0 1.0
NE2 A:HIS42 2.1 17.9 1.0
NE2 A:HIS40 2.1 18.5 1.0
NE2 A:HIS28 2.1 17.3 1.0
O A:HOH257 2.2 25.3 1.0
OE2 A:GLU160 2.6 30.0 1.0
CE1 A:HIS40 3.0 20.4 1.0
CE1 A:HIS28 3.0 18.0 1.0
CE1 A:HIS42 3.1 16.9 1.0
CD2 A:HIS42 3.1 17.0 1.0
CD2 A:HIS28 3.2 16.2 1.0
CD2 A:HIS40 3.2 17.3 1.0
CD A:GLU160 3.3 37.3 1.0
OE1 A:GLU160 3.6 38.3 1.0
O6 A:XTN211 4.0 25.6 1.0
OE2 A:GLU37 4.1 22.7 1.0
ND1 A:HIS40 4.2 18.9 1.0
ND1 A:HIS28 4.2 16.4 1.0
ND1 A:HIS42 4.2 17.6 1.0
CG A:HIS42 4.2 16.3 1.0
CG A:GLU160 4.2 31.5 1.0
CG A:HIS40 4.3 17.4 1.0
CG A:HIS28 4.3 15.2 1.0
O A:HOH223 4.7 19.5 1.0
OH A:TYR44 4.8 18.4 1.0
CD A:GLU37 4.9 27.4 1.0
C6 A:XTN211 5.0 22.6 1.0
OE1 A:GLU37 5.0 35.8 1.0

Reference:

E.T.Larson, J.Bosch, J.E.Kim, N.Mueller, C.L.M.J.Verlinde, W.C.Van Voorhis, F.S.Buckner, E.Fan, W.G.J.Hol, E.A.Merritt. Structural Analysis of the Dual-Functional 6-Pyruvoyltetrahydropterin Synthase From Malaria Parasites. To Be Published.
Page generated: Sat Oct 26 08:57:20 2024

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