Zinc in PDB 3fcz: Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility

All present enzymatic activity of Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility:
3.5.2.6;

The structure of Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility, PDB code: 3fcz was solved by P.Tomatis, S.Fabiane, F.Simona, P.Carloni, B.Sutton, A.Vila, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	72.60 / 2.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	69.670, 48.810, 77.190, 90.00, 109.86, 90.00
R / Rfree (%)	19.4 / 25.8

The binding sites of Zinc atom in the Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility (pdb code 3fcz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility, PDB code: 3fcz:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn292 b:52.6 occ:1.00 NE2 A:HIS196 2.1 51.7 1.0 ND1 A:HIS118 2.2 59.1 1.0 NE2 A:HIS116 2.3 51.6 1.0 CD2 A:HIS196 2.9 49.8 1.0 CG A:HIS118 3.0 59.6 1.0 CE1 A:HIS116 3.1 49.7 1.0 CB A:HIS118 3.1 57.7 1.0 CE1 A:HIS196 3.2 53.5 1.0 CE1 A:HIS118 3.3 61.4 1.0 CD2 A:HIS116 3.4 51.4 1.0 ZN A:ZN293 3.4 63.7 1.0 OD1 A:ASP120 3.6 65.6 1.0 SG A:CYS221 3.8 51.9 1.0 CB A:CYS221 4.1 52.0 1.0 CG A:HIS196 4.2 50.4 1.0 CD2 A:HIS118 4.2 62.5 1.0 OD2 A:ASP120 4.2 63.1 1.0 ND1 A:HIS196 4.3 52.6 1.0 NE2 A:HIS118 4.3 63.6 1.0 ND1 A:HIS116 4.3 48.2 1.0 CG A:ASP120 4.4 64.5 1.0 CG2 A:THR197 4.4 56.2 1.0 CG A:HIS116 4.4 49.2 1.0 CA A:HIS118 4.6 57.7 1.0

Zinc binding site 2 out of 4 in the Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn293 b:63.7 occ:1.00 OD2 A:ASP120 2.5 63.1 1.0 SG A:CYS221 2.6 51.9 1.0 NE2 A:HIS263 2.6 77.6 1.0 CG A:ASP120 3.2 64.5 1.0 OD1 A:ASP120 3.4 65.6 1.0 ZN A:ZN292 3.4 52.6 1.0 CD2 A:HIS263 3.5 77.9 1.0 CB A:CYS221 3.6 52.0 1.0 CE1 A:HIS263 3.6 79.3 1.0 NE2 A:HIS196 3.9 51.7 1.0 CE1 A:HIS196 3.9 53.5 1.0 OG A:SER262 4.4 61.7 1.0 CB A:ASP120 4.5 65.4 1.0 CG A:HIS263 4.7 79.9 1.0 ND1 A:HIS263 4.7 80.7 1.0 CA A:CYS221 4.8 51.2 1.0 NE2 A:HIS116 4.9 51.6 1.0 CE1 A:HIS116 4.9 49.7 1.0 CD2 A:HIS196 4.9 49.8 1.0 ND1 A:HIS196 4.9 52.6 1.0

Zinc binding site 3 out of 4 in the Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn292 b:46.8 occ:1.00 NE2 B:HIS196 2.2 46.2 1.0 ND1 B:HIS118 2.2 62.4 1.0 NE2 B:HIS116 2.2 41.9 1.0 CG B:HIS118 3.0 63.4 1.0 CD2 B:HIS196 3.0 44.4 1.0 CE1 B:HIS116 3.1 39.8 1.0 CB B:HIS118 3.1 61.7 1.0 CE1 B:HIS196 3.3 47.5 1.0 CD2 B:HIS116 3.3 41.8 1.0 CE1 B:HIS118 3.3 64.7 1.0 ZN B:ZN293 3.4 50.7 1.0 OD1 B:ASP120 3.6 49.1 1.0 SG B:CYS221 3.8 43.2 1.0 CB B:CYS221 4.1 42.8 1.0 O B:HOH299 4.2 43.6 1.0 CD2 B:HIS118 4.2 66.4 1.0 CG B:HIS196 4.2 44.6 1.0 ND1 B:HIS116 4.2 38.5 1.0 OD2 B:ASP120 4.2 46.3 1.0 ND1 B:HIS196 4.3 46.5 1.0 NE2 B:HIS118 4.3 67.2 1.0 CG B:ASP120 4.3 47.9 1.0 CG B:HIS116 4.4 39.7 1.0 CG2 B:THR197 4.4 45.6 1.0 CA B:HIS118 4.6 62.2 1.0 O B:HOH11 4.8 15.7 1.0

Zinc binding site 4 out of 4 in the Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn293 b:50.7 occ:1.00 OD2 B:ASP120 2.3 46.3 1.0 SG B:CYS221 2.5 43.2 1.0 NE2 B:HIS263 2.6 61.0 1.0 CG B:ASP120 3.0 47.9 1.0 O B:HOH11 3.0 15.7 1.0 O B:HOH299 3.1 43.6 1.0 OD1 B:ASP120 3.1 49.1 1.0 O B:HOH1 3.3 9.9 1.0 ZN B:ZN292 3.4 46.8 1.0 CE1 B:HIS263 3.5 62.8 1.0 CD2 B:HIS263 3.6 60.9 1.0 CB B:CYS221 3.6 42.8 1.0 NE2 B:HIS196 4.0 46.2 1.0 CE1 B:HIS196 4.1 47.5 1.0 CB B:ASP120 4.2 49.0 1.0 OG B:SER262 4.4 41.9 1.0 ND1 B:HIS263 4.7 63.9 1.0 CG B:HIS263 4.7 62.8 1.0 NE2 B:HIS116 4.8 41.9 1.0 CE1 B:HIS116 4.8 39.8 1.0 CA B:CYS221 4.8 41.8 1.0

P.E.Tomatis, S.M.Fabiane, F.Simona, P.Carloni, B.J.Sutton, A.J.Vila. Adaptive Protein Evolution Grants Organismal Fitness By Improving Catalysis and Flexibility. Proc.Natl.Acad.Sci.Usa V. 105 20605 2008.
ISSN: ISSN 0027-8424
PubMed: 19098096
DOI: 10.1073/PNAS.0807989106