Zinc in PDB 3exj: Crystal Structure of A P53 Core Tetramer Bound to Dna

The structure of Crystal Structure of A P53 Core Tetramer Bound to Dna, PDB code: 3exj was solved by K.A.Malecka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.70 / 2.00
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	114.740, 68.016, 75.162, 90.00, 111.12, 90.00
R / Rfree (%)	22.5 / 26

The binding sites of Zinc atom in the Crystal Structure of A P53 Core Tetramer Bound to Dna (pdb code 3exj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of A P53 Core Tetramer Bound to Dna, PDB code: 3exj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of A P53 Core Tetramer Bound to Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of A P53 Core Tetramer Bound to Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:26.6 occ:1.00 ND1 A:HIS176 2.2 19.9 1.0 SG A:CYS239 2.3 26.2 1.0 SG A:CYS173 2.4 25.0 1.0 SG A:CYS235 2.4 25.1 1.0 CB A:CYS239 3.1 24.9 1.0 CE1 A:HIS176 3.1 26.8 1.0 CG A:HIS176 3.2 26.9 1.0 CB A:CYS235 3.3 22.4 1.0 CB A:CYS173 3.5 23.5 1.0 CB A:HIS176 3.5 25.7 1.0 CA A:CYS235 3.8 24.1 1.0 N A:CYS173 3.9 26.7 1.0 NE2 A:HIS176 4.2 27.5 1.0 CA A:CYS173 4.3 26.2 1.0 CE B:MET240 4.3 36.6 1.0 CD2 A:HIS176 4.3 24.8 1.0 N A:HIS176 4.4 26.5 1.0 N A:ASN236 4.5 24.6 1.0 CA A:CYS239 4.5 26.6 1.0 O A:MET234 4.6 26.8 1.0 CA A:HIS176 4.6 28.6 1.0 C A:CYS235 4.7 24.0 1.0 O A:HOH53 4.7 26.0 1.0 O A:CYS173 4.9 25.2 1.0 C A:CYS173 4.9 26.4 1.0 N A:CYS235 5.0 23.9 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of A P53 Core Tetramer Bound to Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of A P53 Core Tetramer Bound to Dna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2 b:27.2 occ:1.00 ND1 B:HIS176 2.1 21.0 1.0 SG B:CYS173 2.3 24.2 1.0 SG B:CYS239 2.4 26.0 1.0 SG B:CYS235 2.5 25.7 1.0 CE1 B:HIS176 3.0 26.3 1.0 CB B:CYS239 3.2 26.8 1.0 CG B:HIS176 3.2 27.0 1.0 CB B:CYS173 3.4 23.4 1.0 CB B:CYS235 3.4 24.3 1.0 CB B:HIS176 3.6 27.2 1.0 CA B:CYS235 3.9 24.8 1.0 N B:CYS173 3.9 26.1 1.0 NE2 B:HIS176 4.1 27.8 1.0 CE A:MET240 4.2 37.2 1.0 CA B:CYS173 4.3 25.1 1.0 CD2 B:HIS176 4.3 25.8 1.0 N B:HIS176 4.4 27.6 1.0 N B:ASN236 4.5 24.2 1.0 CA B:CYS239 4.6 28.2 1.0 O B:MET234 4.6 27.6 1.0 CA B:HIS176 4.7 28.3 1.0 O B:HOH380 4.7 23.5 1.0 C B:CYS235 4.7 25.4 1.0 C B:CYS173 4.9 25.9 1.0 O B:CYS173 5.0 26.1 1.0

K.A.Malecka, W.C.Ho, R.Marmorstein. Crystal Structure of A P53 Core Tetramer Bound to Dna. Oncogene V. 28 325 2009.
ISSN: ISSN 0950-9232
PubMed: 18978813
DOI: 10.1038/ONC.2008.400