Zinc in PDB 3e73: Crystal Structure of Human LANCL1 Complexed with Gsh

The structure of Crystal Structure of Human LANCL1 Complexed with Gsh, PDB code: 3e73 was solved by W.Zhang, G.Zhu, X.Li, Z.Rao, C.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.33 / 2.80
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	194.100, 194.101, 243.554, 90.00, 90.00, 120.00
R / Rfree (%)	23.1 / 26.2

The binding sites of Zinc atom in the Crystal Structure of Human LANCL1 Complexed with Gsh (pdb code 3e73). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human LANCL1 Complexed with Gsh, PDB code: 3e73:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human LANCL1 Complexed with Gsh


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human LANCL1 Complexed with Gsh within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:88.5 occ:1.00 ND1 A:HIS323 2.0 70.9 1.0 SG A:CYS322 2.2 0.3 1.0 SG A:CYS276 2.2 72.4 1.0 SG2 A:GSH502 2.3 69.9 1.0 CE1 A:HIS323 2.8 94.9 1.0 CG A:HIS323 3.1 66.9 1.0 CA2 A:GSH502 3.2 76.4 1.0 C2 A:GSH502 3.2 78.6 1.0 CB A:CYS276 3.2 71.1 1.0 CB2 A:GSH502 3.4 74.0 1.0 CB A:HIS323 3.6 58.7 1.0 O2 A:GSH502 3.7 78.5 1.0 CB A:CYS322 3.8 73.5 1.0 NE2 A:HIS323 3.9 75.5 1.0 O A:CYS322 4.0 53.7 1.0 CD2 A:HIS323 4.0 67.9 1.0 C A:CYS322 4.1 55.8 1.0 N A:HIS323 4.3 56.0 1.0 OH A:TYR62 4.3 66.5 1.0 ND1 A:HIS274 4.4 72.0 1.0 N3 A:GSH502 4.5 77.8 1.0 CA A:CYS322 4.5 58.7 1.0 N2 A:GSH502 4.6 75.4 1.0 CA A:HIS323 4.6 47.2 1.0 CA A:CYS276 4.6 71.2 1.0 CB A:HIS274 4.8 71.7 1.0 OE1 A:GSH502 4.9 84.5 1.0 N A:CYS276 4.9 70.9 1.0 CG A:HIS274 5.0 71.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human LANCL1 Complexed with Gsh


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human LANCL1 Complexed with Gsh within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn502 b:98.2 occ:1.00 SG B:CYS322 2.1 0.6 1.0 ND1 B:HIS323 2.2 67.4 1.0 SG B:CYS276 2.2 79.5 1.0 SG2 B:GSH503 2.4 79.1 1.0 C2 B:GSH503 2.9 79.6 1.0 CE1 B:HIS323 3.0 72.4 1.0 CB2 B:GSH503 3.0 68.2 1.0 CA2 B:GSH503 3.0 80.0 1.0 CG B:HIS323 3.1 0.1 1.0 CB B:CYS276 3.4 59.2 1.0 CB B:HIS323 3.6 97.0 1.0 O2 B:GSH503 3.6 81.9 1.0 CB B:CYS322 3.8 86.8 1.0 O B:CYS322 4.0 72.4 1.0 NE2 B:HIS323 4.0 89.8 1.0 C B:CYS322 4.1 67.4 1.0 ND1 B:HIS274 4.1 90.8 1.0 CD2 B:HIS323 4.1 88.7 1.0 N3 B:GSH503 4.1 78.5 1.0 OH B:TYR62 4.2 86.3 1.0 N B:HIS323 4.3 69.5 1.0 N2 B:GSH503 4.4 82.8 1.0 CA B:CYS322 4.6 72.6 1.0 CA B:HIS323 4.6 58.0 1.0 CA B:CYS276 4.7 90.9 1.0 CG1 B:GSH503 4.8 85.9 1.0 CB B:HIS274 4.8 75.7 1.0 CG B:HIS274 4.9 67.5 1.0 CE1 B:HIS274 4.9 1.0 1.0

W.Zhang, L.Wang, Y.Liu, J.Xu, G.Zhu, H.Cang, X.Li, M.Bartlam, K.Hensley, G.Li, Z.Rao, X.C.Zhang. Structure of Human Lanthionine Synthetase C-Like Protein 1 and Its Interaction with EPS8 and Glutathione Genes Dev. V. 23 1387 2009.
ISSN: ISSN 0890-9369
PubMed: 19528316
DOI: 10.1101/GAD.1789209