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Atomistry » Zinc » PDB 2xk5-2xxi » 2xx8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 2xk5-2xxi » 2xx8 » |
Zinc in PDB 2xx8: Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.Protein crystallography data
The structure of Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution., PDB code: 2xx8
was solved by
S.E.Ward,
M.Harries,
L.Aldegheri,
N.E.Austin,
S.Ballantine,
E.Ballini,
D.M.Bradley,
B.D.Bax,
B.P.Clarke,
A.J.Harris,
S.A.Harrison,
R.A.Melarange,
C.Mookherjee,
J.Mosley,
G.Dalnegro,
B.Oliosi,
K.J.Smith,
K.M.Thewlis,
P.M.Woollard,
S.P.Yusaf,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2xx8:
The structure of Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution. also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.
(pdb code 2xx8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution., PDB code: 2xx8: Jump to Zinc binding site number: 1; 2; 3; 4; 5; Zinc binding site 1 out of 5 in 2xx8Go back to![]() ![]()
Zinc binding site 1 out
of 5 in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 5 in 2xx8Go back to![]() ![]()
Zinc binding site 2 out
of 5 in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.
![]() Mono view ![]() Stereo pair view
Zinc binding site 3 out of 5 in 2xx8Go back to![]() ![]()
Zinc binding site 3 out
of 5 in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.
![]() Mono view ![]() Stereo pair view
Zinc binding site 4 out of 5 in 2xx8Go back to![]() ![]()
Zinc binding site 4 out
of 5 in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.
![]() Mono view ![]() Stereo pair view
Zinc binding site 5 out of 5 in 2xx8Go back to![]() ![]()
Zinc binding site 5 out
of 5 in the Crystal Structure of N,N-Dimethyl-4-(3-(Trifluoromethyl)-4, 5,6,7-Tetrahydro-1H-Indazol-1-Yl)Benzamide in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 2.2A Resolution.
![]() Mono view ![]() Stereo pair view
Reference:
S.E.Ward,
M.Harries,
L.Aldegheri,
N.E.Austin,
S.Ballantine,
E.Ballini,
D.M.Bradley,
B.D.Bax,
B.P.Clarke,
A.J.Harris,
S.A.Harrison,
R.A.Melarange,
C.Mookherjee,
J.Mosley,
G.Dal Negro,
B.Oliosi,
K.J.Smith,
K.M.Thewlis,
P.M.Woollard,
S.P.Yusaf.
Integration of Lead Optimization with Crystallography For A Membrane-Bound Ion Channel Target: Discovery of A New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem. V. 54 78 2011.
Page generated: Thu Oct 17 05:33:03 2024
ISSN: ISSN 0022-2623 PubMed: 21128618 DOI: 10.1021/JM100679E |
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