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Zinc in PDB 2w3q: Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans

Enzymatic activity of Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans

All present enzymatic activity of Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans:
4.2.1.1;

Protein crystallography data

The structure of Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans, PDB code: 2w3q was solved by C.Schlicker, R.A.Hall, D.Vullo, S.Middelhaufe, M.Gertz, C.T.Supuran, F.A.Muehlschlegel, C.Steegborn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.8 / 1.34
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 55.190, 55.190, 134.590, 90.00, 90.00, 120.00
R / Rfree (%) 13.8 / 18.46

Other elements in 2w3q:

The structure of Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans (pdb code 2w3q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans, PDB code: 2w3q:

Zinc binding site 1 out of 1 in 2w3q

Go back to Zinc Binding Sites List in 2w3q
Zinc binding site 1 out of 1 in the Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1231

b:9.5
occ:1.00
 NE2 A:HIS124 2.1 7.2 1.0
O A:HOH2165 2.1 9.0 1.0
SG A:CYS68 2.3 8.4 1.0
SG A:CYS127 2.3 8.5 1.0
CD2 A:HIS124 3.1 8.4 1.0
CE1 A:HIS124 3.1 6.8 1.0
CB A:CYS127 3.2 8.0 1.0
CB A:CYS68 3.3 7.5 1.0
CA A:CYS127 3.5 6.8 1.0
CB A:ASP70 3.9 7.4 1.0
OD2 A:ASP70 4.1 8.8 1.0
N A:GLY128 4.1 8.4 1.0
ND1 A:HIS124 4.1 7.0 1.0
CG A:HIS124 4.2 6.5 1.0
C A:CYS127 4.2 8.2 1.0
O A:HOH2083 4.2 8.4 1.0
CA A:ALA93 4.4 8.3 1.0
CG A:ASP70 4.5 6.3 1.0
N A:ALA93 4.5 8.1 1.0
N A:CYS127 4.7 7.7 1.0
CA A:CYS68 4.7 6.2 1.0
N A:ASP70 4.8 7.7 1.0
OD1 A:ASN94 4.9 9.6 1.0
CA A:ASP70 4.9 7.6 1.0

Reference:

C.Schlicker, R.A.Hall, D.Vullo, S.Middelhaufe, M.Gertz, C.T.Supuran, F.A.Muehlschlegel, C.Steegborn. Structure and Inhibition of the Co(2)-Sensing Carbonic Anhydrase CAN2 From the Pathogenic Fungus Cryptococcus Neoformans. J.Mol.Biol. V. 385 1207 2009.
ISSN: ISSN 0022-2836
PubMed: 19071134
DOI: 10.1016/J.JMB.2008.11.037
Page generated: Thu Oct 17 04:43:51 2024

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