Zinc in PDB 2vrw: Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor

The structure of Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor, PDB code: 2vrw was solved by J.Rapley, V.Tybulewicz, K.Rittinger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.00 / 1.85
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	122.763, 62.143, 103.281, 90.00, 118.80, 90.00
R / Rfree (%)	20.3 / 25.1

The binding sites of Zinc atom in the Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor (pdb code 2vrw). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor, PDB code: 2vrw:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1565 b:22.6 occ:1.00 ND1 B:HIS516 2.1 20.2 1.0 SG B:CYS546 2.3 23.2 1.0 SG B:CYS549 2.3 23.6 1.0 SG B:CYS564 2.4 25.4 1.0 CE1 B:HIS516 2.9 20.8 1.0 CB B:CYS546 3.1 22.8 1.0 CG B:HIS516 3.2 21.2 1.0 CB B:CYS564 3.3 25.7 1.0 CB B:CYS549 3.3 23.5 1.0 CB B:HIS516 3.6 22.0 1.0 N B:CYS549 3.7 23.9 1.0 CA B:HIS516 3.7 22.5 1.0 CA B:CYS564 3.8 25.8 1.0 CA B:CYS549 4.1 23.5 1.0 NE2 B:HIS516 4.1 20.8 1.0 CD2 B:HIS516 4.2 20.5 1.0 CB B:ARG548 4.3 24.4 1.0 O B:HOH2075 4.5 33.5 1.0 N B:HIS516 4.6 22.2 1.0 CA B:CYS546 4.6 22.8 1.0 C B:ARG548 4.7 24.3 1.0 N B:ASP517 4.7 23.6 1.0 C B:HIS516 4.8 23.2 1.0 N B:CYS564 4.8 25.8 1.0 C B:CYS564 4.8 25.8 1.0 CA B:ARG548 4.8 24.5 1.0 C B:CYS549 4.8 23.4 1.0 N B:ARG548 4.9 24.4 1.0 O B:GLY515 4.9 21.9 1.0 N B:ARG550 5.0 23.5 1.0

Zinc binding site 2 out of 2 in the Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Critical Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1566 b:22.8 occ:1.00 ND1 B:HIS554 2.2 22.6 1.0 SG B:CYS557 2.3 23.1 1.0 SG B:CYS532 2.3 21.1 1.0 SG B:CYS529 2.3 21.7 1.0 CE1 B:HIS554 3.0 22.5 1.0 CB B:CYS529 3.1 21.6 1.0 CB B:CYS557 3.2 23.1 1.0 CG B:HIS554 3.2 21.2 1.0 CB B:CYS532 3.3 22.2 1.0 CB B:HIS554 3.6 21.4 1.0 N B:CYS532 3.8 22.6 1.0 N B:HIS554 4.1 20.4 1.0 CA B:CYS532 4.2 22.2 1.0 NE2 B:HIS554 4.2 22.7 1.0 O B:HOH2308 4.3 41.3 1.0 CD2 B:HIS554 4.3 22.0 1.0 CA B:HIS554 4.5 21.1 1.0 CA B:CYS529 4.6 22.0 1.0 O B:HOH2063 4.6 54.0 1.0 CA B:CYS557 4.6 23.4 1.0 CB B:ALA531 4.7 22.4 1.0 O B:HOH2059 4.8 34.2 1.0 C B:ALA531 4.9 22.9 1.0 C B:CYS532 4.9 22.1 1.0

J.Rapley, V.Tybulewicz, K.Rittinger. Crucial Structural Role For the pH and C1 Domains of the VAV1 Exchange Factor. Embo Rep. V. 9 655 2008.
ISSN: ISSN 1469-221X
PubMed: 18511940
DOI: 10.1038/EMBOR.2008.80