Zinc in PDB 2uxa: Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited.

The structure of Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited., PDB code: 2uxa was solved by I.H.Greger, P.Akamine, L.Khatri, E.B.Ziff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.56 / 2.38
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	114.254, 164.003, 47.462, 90.00, 90.00, 90.00
R / Rfree (%)	17.4 / 26.5

The binding sites of Zinc atom in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited. (pdb code 2uxa). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited., PDB code: 2uxa:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1263 b:24.8 occ:1.00 OE1 A:GLU42 2.0 26.8 1.0 OE2 B:GLU166 2.1 17.4 1.0 NE2 A:HIS46 2.2 20.4 1.0 O A:HOH2123 2.4 6.9 1.0 OE1 B:GLU166 2.7 14.5 1.0 CD B:GLU166 2.8 13.1 1.0 CD A:GLU42 3.1 22.9 1.0 CE1 A:HIS46 3.1 18.5 1.0 CD2 A:HIS46 3.2 18.9 1.0 OE2 A:GLU42 3.5 24.1 1.0 O A:HOH2124 3.6 2.0 1.0 CD2 A:LEU241 4.2 4.4 1.0 N B:SER168 4.2 16.4 1.0 ND1 A:HIS46 4.2 17.2 1.0 CG A:HIS46 4.3 19.7 1.0 CG B:GLU166 4.3 14.4 1.0 CG A:GLU42 4.4 18.1 1.0 CA B:PRO167 4.6 15.9 1.0 C B:PRO167 4.7 15.9 1.0 CB A:GLU42 4.8 15.2 1.0 CB B:GLU166 4.9 17.0 1.0 CA B:GLU166 4.9 16.7 1.0 CA B:SER168 4.9 17.4 1.0 O B:HOH2097 5.0 19.6 1.0 O B:ALA165 5.0 14.4 1.0

Zinc binding site 2 out of 5 in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1262 b:23.4 occ:1.00 NE2 B:HIS23 2.0 16.1 1.0 OE2 B:GLU30 2.5 26.2 1.0 OE1 B:GLU30 2.7 25.1 1.0 CD B:GLU30 3.0 23.8 1.0 CD2 B:HIS23 3.0 14.8 1.0 CE1 B:HIS23 3.0 14.3 1.0 NZ B:LYS20 4.1 14.8 1.0 CD B:LYS20 4.1 9.3 1.0 ND1 B:HIS23 4.1 16.2 1.0 CG B:HIS23 4.1 16.0 1.0 O B:GLU30 4.4 17.1 1.0 CG B:GLU30 4.5 23.8 1.0 CD2 B:LEU26 4.6 26.4 1.0 CE B:LYS20 4.6 14.2 1.0

Zinc binding site 3 out of 5 in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1263 b:33.1 occ:1.00 NE2 B:HIS46 2.0 18.3 1.0 OE1 B:GLU42 2.1 19.4 1.0 CE1 B:HIS46 2.9 17.6 1.0 CD B:GLU42 3.1 20.9 1.0 CD2 B:HIS46 3.1 21.3 1.0 OE2 B:GLU42 3.4 22.6 1.0 CD2 B:LEU241 3.5 9.2 1.0 NZ B:LYS45 3.8 21.7 1.0 OE1 B:GLN244 3.8 23.9 1.0 ND1 B:HIS46 4.1 18.9 1.0 CG B:HIS46 4.2 20.8 1.0 CG B:GLU42 4.4 15.6 1.0 CE B:LYS45 4.4 21.3 1.0 CB B:GLU42 4.7 12.9 1.0 CD B:GLN244 4.7 23.1 1.0 NE2 B:GLN244 4.8 22.4 1.0 CG B:LEU241 5.0 12.1 1.0

Zinc binding site 4 out of 5 in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1263 b:33.2 occ:1.00 O C:HOH2133 1.8 14.5 1.0 OD2 C:ASP65 2.2 29.2 1.0 O C:HOH2134 2.5 21.6 1.0 OD1 C:ASP65 2.9 29.4 1.0 CG C:ASP65 2.9 24.5 1.0 OD2 C:ASP67 3.9 31.9 1.0 O C:HOH2039 4.3 30.4 1.0 CB C:ASP65 4.3 19.9 1.0 CB C:ASP67 4.4 24.6 1.0 CG C:ASP67 4.5 26.7 1.0 OG1 C:THR68 4.9 22.9 1.0

Zinc binding site 5 out of 5 in the Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Crystal Structure of the GLUR2-Flip Ligand Binding Domain, R/G Unedited. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1264 b:41.4 occ:1.00 OE1 C:GLU42 2.2 23.4 1.0 CE1 C:HIS46 2.4 28.3 1.0 NZ C:LYS45 2.9 27.5 1.0 O C:HOH2024 3.2 23.7 1.0 CD C:GLU42 3.3 23.0 1.0 NE2 C:HIS46 3.3 28.7 1.0 ND1 C:HIS46 3.3 30.2 1.0 CE C:LYS45 3.4 30.8 1.0 OE2 C:GLU42 3.7 28.4 1.0 CD2 C:LEU241 3.8 16.0 1.0 OE1 C:GLN244 4.2 38.2 1.0 O C:HOH2128 4.4 19.9 1.0 CD2 C:HIS46 4.5 26.9 1.0 CG C:HIS46 4.5 27.8 1.0 CD C:LYS45 4.6 26.7 1.0 CG C:GLU42 4.6 18.9 1.0 CB C:GLU42 4.8 17.4 1.0 O C:GLU42 4.9 19.3 1.0

I.H.Greger, P.Akamine, L.Khatri, E.B.Ziff. Developmentally Regulated, Combinatorial Rna Processing Modulates Ampa Receptor Biogenesis. Neuron V. 51 85 2006.
ISSN: ISSN 0896-6273
PubMed: 16815334
DOI: 10.1016/J.NEURON.2006.05.020