Zinc in PDB 2uvl: Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3)

The structure of Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3), PDB code: 2uvl was solved by M.Moche, L.Lehtio, C.Arrowsmith, H.Berglund, R.Busam, R.Collins, L.G.Dahlgren, A.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg-Schiavone, I.Johansson, T.Karlberg, T.Kotenyova, T.Nyman, D.Ogg, C.Persson, J.Sagemark, P.Stenmark, M.Sundstrom, A.G.Thorsell, M.Upsten, S.Van Den Berg, J.Weigelt, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.91
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	49.410, 53.720, 85.610, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 24

The binding sites of Zinc atom in the Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3) (pdb code 2uvl). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3), PDB code: 2uvl:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1336 b:19.9 occ:1.00 NE2 A:HIS312 1.9 14.3 1.0 SG A:CYS292 2.4 18.1 1.0 SG A:CYS319 2.4 21.7 1.0 SG A:CYS295 2.5 19.9 1.0 CE1 A:HIS312 2.7 20.5 1.0 CB A:CYS292 3.1 19.0 1.0 CD2 A:HIS312 3.1 20.2 1.0 CB A:CYS319 3.1 21.8 1.0 CB A:CYS295 3.3 21.5 1.0 N A:CYS295 3.6 21.2 1.0 ND1 A:HIS312 3.9 19.0 1.0 CA A:CYS295 4.0 22.2 1.0 CG A:HIS312 4.1 20.8 1.0 CA A:CYS319 4.4 24.0 1.0 CB A:CYS294 4.4 21.1 1.0 CA A:CYS292 4.5 18.3 1.0 C A:CYS294 4.7 22.5 1.0 CB A:PHE316 4.8 25.6 1.0 C A:CYS295 4.9 23.4 1.0 N A:CYS294 5.0 21.1 1.0 CA A:CYS294 5.0 21.5 1.0

Zinc binding site 2 out of 2 in the Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human BIR3 Domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1338 b:20.5 occ:1.00 NE2 B:HIS312 2.0 18.1 1.0 SG B:CYS292 2.3 20.1 1.0 SG B:CYS295 2.4 21.8 1.0 SG B:CYS319 2.4 21.2 1.0 CE1 B:HIS312 2.8 21.0 1.0 CB B:CYS292 3.1 18.4 1.0 CB B:CYS319 3.1 22.1 1.0 CD2 B:HIS312 3.2 19.9 1.0 CB B:CYS295 3.3 23.0 1.0 N B:CYS295 3.6 23.3 1.0 ND1 B:HIS312 4.0 20.3 1.0 CA B:CYS295 4.0 23.6 1.0 CG B:HIS312 4.2 20.1 1.0 CA B:CYS319 4.4 24.2 1.0 CB B:CYS294 4.5 23.6 1.0 CA B:CYS292 4.6 19.1 1.0 C B:CYS294 4.8 25.3 1.0 CB B:PHE316 4.8 26.2 1.0 C B:CYS295 4.8 24.3 1.0 N B:CYS294 5.0 23.4 1.0 CA B:CYS294 5.0 23.9 1.0 N B:ASP296 5.0 24.8 1.0

M.D.Herman, M.Moche, S.Flodin, M.Welin, L.Tresaugues, I.Johansson, M.Nilsson, P.Nordlund, T.Nyman. Structures of Bir Domains From Human Naip and CIAP2. Acta Crystallogr.,Sect.F V. 65 1091 2009.
ISSN: ESSN 1744-3091
PubMed: 19923725
DOI: 10.1107/S1744309109038597