Zinc in PDB 2rf5: Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain

All present enzymatic activity of Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain:
2.4.2.30;

The structure of Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain, PDB code: 2rf5 was solved by L.Lehtio, T.Karlberg, C.H.Arrowsmith, H.Berglund, R.Busam, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, M.D.Herman, L.Holmberg-Schiavone, I.Johansson, A.Kallas, T.Kotenyova, M.Moche, P.Nordlund, T.Nyman, C.Persson, J.Sagemark, M.Sundstrom, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, M.Welin, J.Weigelt, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.44 / 2.30
Space group	I 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	79.950, 81.240, 82.720, 90.00, 90.00, 90.00
R / Rfree (%)	19.3 / 25

The binding sites of Zinc atom in the Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain (pdb code 2rf5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain, PDB code: 2rf5:

Zinc binding site 1 out of 1 in the Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Tankyrase 1- Catalytic Parp Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:27.3 occ:1.00 SG A:CYS1242 2.1 24.0 1.0 SG A:CYS1234 2.2 21.3 1.0 ND1 A:HIS1237 2.3 23.6 1.0 SG A:CYS1245 2.4 24.2 1.0 CG A:HIS1237 3.2 23.6 1.0 CB A:CYS1234 3.3 25.1 1.0 CB A:CYS1242 3.3 24.5 1.0 CE1 A:HIS1237 3.4 21.2 1.0 CB A:CYS1245 3.4 22.4 1.0 CB A:HIS1237 3.4 23.8 1.0 N A:HIS1237 3.9 24.9 1.0 O A:HOH1380 4.1 30.8 1.0 N A:CYS1245 4.1 21.8 1.0 CA A:HIS1237 4.2 24.8 1.0 CA A:CYS1245 4.4 22.5 1.0 CD2 A:HIS1237 4.4 21.3 1.0 NE2 A:HIS1237 4.4 20.0 1.0 CB A:THR1236 4.5 25.2 1.0 O A:HOH1378 4.6 20.4 1.0 CA A:CYS1234 4.7 25.7 1.0 CA A:CYS1242 4.7 24.0 1.0 CB A:ILE1244 4.8 22.4 1.0 C A:THR1236 4.8 25.1 1.0 N A:THR1236 4.9 25.2 1.0 OG1 A:THR1236 5.0 26.3 1.0 O A:HOH1365 5.0 21.9 1.0 CA A:THR1236 5.0 25.0 1.0

L.Lehtio, R.Collins, S.Van Den Berg, A.Johansson, L.G.Dahlgren, M.Hammarstrom, T.Helleday, L.Holmberg-Schiavone, T.Karlberg, J.Weigelt. Zinc Binding Catalytic Domain of Human Tankyrase 1. J.Mol.Biol. V. 379 136 2008.
ISSN: ISSN 0022-2836
PubMed: 18436240
DOI: 10.1016/J.JMB.2008.03.058