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Zinc in PDB 2qds: Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril

Enzymatic activity of Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril

All present enzymatic activity of Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril:
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril, PDB code: 2qds was solved by G.Garau, O.Dideberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.66
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 43.001, 100.990, 116.819, 90.00, 90.00, 90.00
R / Rfree (%) 14.8 / 17

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril (pdb code 2qds). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril, PDB code: 2qds:

Zinc binding site 1 out of 1 in 2qds

Go back to Zinc Binding Sites List in 2qds
Zinc binding site 1 out of 1 in the Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Zinc Carbapenemase Cpha in Complex with the Inhibitor D-Captopril within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:14.6
occ:1.00
 OD2 A:ASP120 2.0 12.4 1.0
O2 A:MCO501 2.0 24.4 1.0
NE2 A:HIS263 2.1 12.6 1.0
SG A:CYS221 2.3 13.5 1.0
CG A:ASP120 3.0 12.0 1.0
CE1 A:HIS263 3.0 11.7 1.0
C9 A:MCO501 3.1 30.2 1.0
CD2 A:HIS263 3.2 12.6 1.0
OD1 A:ASP120 3.3 11.8 1.0
CB A:CYS221 3.4 12.8 1.0
C8 A:MCO501 3.5 30.7 1.0
O A:HOH608 3.8 23.6 1.0
NH2 A:ARG121 3.9 12.0 1.0
C7 A:MCO501 4.0 31.1 1.0
ND1 A:HIS263 4.2 11.2 1.0
O3 A:MCO501 4.2 29.0 1.0
CA A:CYS221 4.3 12.7 1.0
CG A:HIS263 4.3 11.6 1.0
CB A:ASP120 4.3 9.5 1.0
O A:HOH609 4.4 52.0 1.0
CZ A:ARG121 4.4 9.8 1.0
CE1 A:HIS196 4.4 15.9 1.0
NE A:ARG121 4.4 9.0 1.0
NE2 A:HIS196 4.6 16.0 1.0
N A:MCO501 4.9 31.4 1.0
O1 A:MCO501 4.9 32.3 1.0
N A:CYS221 4.9 12.5 1.0

Reference:

B.M.Lienard, G.Garau, L.Horsfall, A.I.Karsisiotis, C.Damblon, P.Lassaux, C.Papamicael, G.C.Roberts, M.Galleni, O.Dideberg, J.M.Frere, C.J.Schofield. Structural Basis For the Broad-Spectrum Inhibition of Metallo-Beta-Lactamases By Thiols. Org.Biomol.Chem. V. 6 2282 2008.
ISSN: ISSN 1477-0520
PubMed: 18563261
DOI: 10.1039/B802311E
Page generated: Wed Aug 20 05:21:28 2025

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