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Zinc in PDB 2ow6: Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride

Enzymatic activity of Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride

All present enzymatic activity of Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride:
3.2.1.114;

Protein crystallography data

The structure of Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride, PDB code: 2ow6 was solved by D.A.Kuntz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.19
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 69.007, 109.620, 138.915, 90.00, 90.00, 90.00
R / Rfree (%) 11.8 / 15

Zinc Binding Sites:

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride (pdb code 2ow6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride, PDB code: 2ow6:

Zinc binding site 1 out of 1 in 2ow6

Go back to Zinc Binding Sites List in 2ow6
Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II Complex with (1R,5S,6S,7R,8S)-1- Thioniabicyclo[4.3.0]Nonan-5,7,8-Triol Chloride within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn3001

b:12.4
occ:1.00
 NE2 A:HIS471 2.0 10.5 1.0
OD1 A:ASP92 2.0 12.0 1.0
NE2 A:HIS90 2.0 11.1 1.0
OD2 A:ASP204 2.0 11.8 1.0
O8 A:NK14001 2.2 11.9 1.0
CG A:ASP92 2.9 12.3 1.0
CD2 A:HIS471 3.0 10.2 1.0
CE1 A:HIS471 3.0 10.6 1.0
CD2 A:HIS90 3.1 11.9 1.0
CE1 A:HIS90 3.1 11.9 1.0
CG A:ASP204 3.1 11.2 1.0
OD2 A:ASP92 3.1 14.3 1.0
C9 A:NK14001 3.2 14.9 1.0
C8 A:NK14001 3.3 12.6 1.0
CB A:ASP204 3.5 11.3 1.0
OD2 A:ASP472 4.0 11.4 1.0
S1 A:NK14001 4.1 16.0 1.0
ND1 A:HIS471 4.2 10.1 1.0
CG A:HIS471 4.2 10.1 1.0
ND1 A:HIS90 4.2 11.4 1.0
CG A:HIS90 4.2 11.0 1.0
OD1 A:ASP204 4.2 12.4 1.0
C6 A:NK14001 4.3 15.2 1.0
CB A:ASP92 4.3 11.3 1.0
C7 A:NK14001 4.3 14.0 1.0
NE2 A:HIS470 4.3 13.3 1.0
O A:HOH5929 4.4 14.5 1.0
OH A:TYR269 4.8 16.6 1.0
CA A:ASP92 4.9 10.8 1.0
O7 A:NK14001 4.9 13.2 1.0
CA A:ASP204 4.9 10.7 1.0
CG A:ASP472 5.0 11.0 1.0

Reference:

N.S.Kumar, D.A.Kuntz, X.Wen, B.M.Pinto, D.R.Rose. Binding of Sulfonium-Ion Analogues of Di-Epi-Swainsonine and 8-Epi-Lentiginosine to Drosophila Golgi Alpha-Mannosidase II: the Role of Water in Inhibitor Binding. Proteins V. 71 1484 2008.
ISSN: ISSN 0887-3585
PubMed: 18076078
DOI: 10.1002/PROT.21850
Page generated: Thu Oct 17 02:50:16 2024

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